Based on previous myopia genome-wide association studies, five SNPs (<i>ZC3H11B</i> rs4373767, <i>ZFHX1B</i> rs13382811, <i>VIPR2</i> rs2730260, <i>SNTB1</i> rs7839488 and <i>MIPEP</i> rs9318086) were selected for genotyping in a Chinese cohort of 2079 subjects: 252 extreme myopia, 277 high myopia, 393 moderate myopia, 366 mild myopia and 791 non-myopic controls.
The 4q25 variant rs10034228 (p=0.002, OR=0.56) and <i>MIPEP</i> variant rs9318086 (p=0.004, OR=1.62) were found to be significantly associated with myopia as well as different severity of myopia.