Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1420101
rs1420101
IL18R1 ; IL1RL1
T 0.710 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs34210653
rs34210653
ALOX15
G 0.710 GeneticVariation GWASCAT Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10<sup>-27</sup>, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P = 1.1 × 10<sup>-8</sup>, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity. 30643255

2019
dbSNP: rs34210653
rs34210653
ALOX15
0.710 GeneticVariation BEFREE Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10<sup>-27</sup>, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P = 1.1 × 10<sup>-8</sup>, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity. 30643255

2019
dbSNP: rs1420101
rs1420101
IL18R1 ; IL1RL1
0.710 GeneticVariation BEFREE Although rs1420101 itself failed to associate with NP, a combined risk assessment of rs3939286 and rs1420101 further increased the risk for NP. 19860791

2010
dbSNP: rs1050152
rs1050152
SLC22A4 ; MIR3936HG
C 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs10905284
rs10905284
GATA3
C 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs1391371
rs1391371
HLA-DQA1
T 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs1444782
rs1444782 		G 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs174535
rs174535
MYRF ; TMEM258
T 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs17718444
rs17718444
FOXP1
C 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs1837253
rs1837253 		C 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs1888909
rs1888909 		T 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs2428494
rs2428494
HLA-B
A 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs28383314
rs28383314 		C 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs338598
rs338598
CYP2S1
C 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs4807542
rs4807542
GPX4
G 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs62408225
rs62408225
BACH2
A 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs6543124
rs6543124
IL18R1
T 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs7302200
rs7302200 		A 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs8046011
rs8046011 		G 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255

2019
dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE The present meta-analysis revealed that TNF alpha rs1800629, increased TNF alpha expression and secretion of nasal mucosal cells were associated with an increased risk of nasal polyposis. 29388847

2018
dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE The frequency of the A allele in a SNP located in tumor necrosis factor (TNF)-alpha (rs1800629) is significantly different in patients with nasal polyposis versus controls without nasal polyposis, 18.6% and 11.5%, respectively with an individuals' odds of susceptibility to nasal polyps increasing almost two-fold (odds ratio, 1.86; confidence interval, 1.4-3.09) given at least one copy of the A allele at this SNP. 19405090

2009
dbSNP: rs113795008
rs113795008
BET1L ; SCGB1C1
0.010 GeneticVariation BEFREE The rs113795008 and rs2280540 variations were significantly high in NP (P= 0.005, P= 0.045). 29412801

2018
dbSNP: rs2280540
rs2280540
BET1L ; SCGB1C1
0.010 GeneticVariation BEFREE The rs113795008 and rs2280540 variations were significantly high in NP (P= 0.005, P= 0.045). 29412801

2018
dbSNP: rs2427827
rs2427827
FCER1A
0.010 GeneticVariation BEFREE Patient stratification revealed a significant association (P < 0.05) of rs2427827 SNP with high IgE level CRSwNP patients. 29243845

2018