rs17576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Heritable polymorphisms modulate metastatic efficiency in Cancer Single nucleotide polymorphisms (SNPs) in MMP9 (rs17576) and SIPA1 (rs746429, rs931127) have been associated with nodal metastases in multiple cancers.
|
19906411 |
2010 |
rs17576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings indicate that the potentially functional polymorphisms, MMP-9 P574R and R279Q, may confer the biomarker in the occurrence and metastasis of primary lung cancer.
|
16061858 |
2005 |
rs3918242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.
|
31810917 |
2019 |
rs17577
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To test our hypothesis that common nonsynonymous SNPs, R279Q, P574R, and R668Q, in MMP-9 are associated with lung cancer development and metastasis, we conducted a case-control study of 744 patients with incident lung cancer and 747 cancer-free controls in Southeast China.
|
16061858 |
2005 |
rs17577
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, after adjustment for age, sex, phenotypic index, moles, and freckles only Q279R, P574R and R668Q had significant associations with intransit metastasis, propensity to tan/sunburn and primary melanoma site.
|
17346338 |
2007 |
rs2250889
|
|
|
0.020 |
GeneticVariation |
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
rs2250889
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, after adjustment for age, sex, phenotypic index, moles, and freckles only Q279R, P574R and R668Q had significant associations with intransit metastasis, propensity to tan/sunburn and primary melanoma site.
|
17346338 |
2007 |