|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MTHFR 1298A>C genotype remained a significant predictor in a multivariate analysis including metastasis characteristics.
|
15608557 |
2004 |
|
rs761872690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the GNB3 825C>T polymorphism does not appear to be associated with breast cancer risk, but may influence development of metastasis in low-grade tumors.
|
15019160 |
2004 |
|
rs765431049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT).
|
14525759 |
2004 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unexpectedly, V599 and V599E mutations were absent in cutaneous/subcutaneous metastases derived from acrolentiginous melanomas as preceding primary tumours.
|
15935100 |
2005 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In line with the previous reports, NRAS/BRAF mutations were rare; only one metastatic tumor had an NRAS E61R mutation, and one primary tumor and two metastases harbored BRAF V599E mutations.
|
16098043 |
2005 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sixty-eight samples (20 of 36 primaries, 18 of 27 regional metastases, 16 of 40 nodal metastases, and 9 of 12 distant metastases) harbored the V599E B-RAF mutation (59%), 17 contained a Q61R N-RAS mutation, and 4 contained a Q61K N-RAS mutation.
|
15737846 |
2005 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sixty-eight samples (20 of 36 primaries, 18 of 27 regional metastases, 16 of 40 nodal metastases, and 9 of 12 distant metastases) harbored the V599E B-RAF mutation (59%), 17 contained a Q61R N-RAS mutation, and 4 contained a Q61K N-RAS mutation.
|
15737846 |
2005 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unexpectedly, V599 and V599E mutations were absent in cutaneous/subcutaneous metastases derived from acrolentiginous melanomas as preceding primary tumours.
|
15935100 |
2005 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In line with the previous reports, NRAS/BRAF mutations were rare; only one metastatic tumor had an NRAS E61R mutation, and one primary tumor and two metastases harbored BRAF V599E mutations.
|
16098043 |
2005 |
|
rs121913227
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The oncogenic B-raf mutations V599E and V599K, as early events in melanocyte transformation, persist throughout metastasis with important prognostic implications.
|
16179870 |
2005 |
|
rs121913227
|
|
|
0.080 |
GeneticVariation |
BEFREE |
As to the B-raf protein sequence, the acidic amino acid transitions V599E and V599K were predicted in 19/60 (32%) and 6/60 (10%) cases, respectively, but were not associated with enhanced risk for subsequent metastasis in patients' follow up.
|
15935100 |
2005 |
|
rs1057519824
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The Y1235D mutation identified in metastases was shown to induce constitutive activation and a motile-invasive phenotype on transduced carcinoma cells.
|
16245927 |
2005 |
|
rs11549465
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The Pro582Ser change in HIF-1alpha was detected in six patients (11%) and was positively correlated with the development of metastases (P=0.023).
|
15809750 |
2005 |
|
rs17576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings indicate that the potentially functional polymorphisms, MMP-9 P574R and R279Q, may confer the biomarker in the occurrence and metastasis of primary lung cancer.
|
16061858 |
2005 |
|
rs17577
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To test our hypothesis that common nonsynonymous SNPs, R279Q, P574R, and R668Q, in MMP-9 are associated with lung cancer development and metastasis, we conducted a case-control study of 744 patients with incident lung cancer and 747 cancer-free controls in Southeast China.
|
16061858 |
2005 |
|
rs2250889
|
|
|
0.020 |
GeneticVariation |
BEFREE |
When we examined the combined effect of R279Q and P574R and used the 279R and 574P as the risk alleles, a significantly increased risk of lung cancer was associated with both the genotypes containing "1 to 2 risk alleles" (adjusted OR, 2.16; 95% CI, 1.30-3.59) and containing ">2 risk alleles" (adjusted OR, 2.44; 95% CI, 1.48-4.03), and it was more pronounced in 290 lung cancer cases with metastasis [adjusted OR, 2.30 (95% CI, 1.09-4.85) for the 1 to 2 risk alleles subgroup and adjusted OR, 2.82 (95% CI, 1.35-5.88) for the >2 risk alleles subgroup], compared with those without any risk alleles.
|
16061858 |
2005 |
|
rs5443
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was no association of GNB3 C825T genotype with tumor stage or grade, but follow-up analysis in the subgroup of non-smokers revealed a shorter time to metastasis in 825T-allele carriers compared to individuals homozygous CC.
|
16133558 |
2005 |
|
rs34296044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the relationship of single nucleotide polymorphisms (SNPs) at exon 10 (T439M) and exon 13 (P757L) of the EXO1 gene with development, progression and metastasis of colorectal cancer.
|
15550454 |
2005 |
|
rs3732379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The V249I polymorphism revealed no association with tumor grade and stage, the presence of extrahepatic metastasis or the degree of fibrosis in non-tumorous tissue.
|
15809764 |
2005 |
|
rs4149963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the relationship of single nucleotide polymorphisms (SNPs) at exon 10 (T439M) and exon 13 (P757L) of the EXO1 gene with development, progression and metastasis of colorectal cancer.
|
15550454 |
2005 |
|
rs486907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In familial pancreatic cancer, however, patients with Arg462Gln variants had more aggressive tumors with more high grade cancers (OR = 15.40, p = 0.009) and more distant metastases (OR = 7.00, p = 0.04) than patients with the wild-type genotype.
|
15981205 |
2005 |
|
rs9350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the relationship of single nucleotide polymorphisms (SNPs) at exon 10 (T439M) and exon 13 (P757L) of the EXO1 gene with development, progression and metastasis of colorectal cancer.
|
15550454 |
2005 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF(V600E) significantly correlated with absence of node metastasis.
|
16452550 |
2006 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this study provides a mechanistic basis for targeting Mek and not B-Raf in the mutant (V600E)B-Raf signaling cascade to inhibit melanoma metastases.
|
16912199 |
2006 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF(V600E) significantly correlated with absence of node metastasis.
|
16452550 |
2006 |