Gene: EGFR ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121434568
rs121434568
EGFR
0.040 GeneticVariation BEFREE The 19del and L858R patients were similar regarding recurrent patterns, except on pleural/chest wall metastasis (26.0% vs. 12.2%, p = 0.007). 29026990

2018
dbSNP: rs121913444
rs121913444
EGFR
0.010 GeneticVariation BEFREE Pyrosequencing of the primary pancreatic tumor antecedent to metastasis showed an uncommon EGFR mutation at L861Q in the kinase domain of exon 21. 29695402

2018
dbSNP: rs121434569
rs121434569
EGFR ; EGFR-AS1
0.090 GeneticVariation BEFREE In addition, genomic rearrangements and late amplification of the EGFR gene likely induced by afatinib treatment following the acquisition of a T790M gefitinib resistance mutation provided further evidence to tie the time of metastasis formation to treatment history. 30694556

2019
dbSNP: rs2227983
rs2227983
EGFR
0.020 GeneticVariation BEFREE Our results show that, in patients with cervical cancer, the R497K polymorphism is correlated with treatment response and the risk of recurrence or metastasis. 31254173

2019
dbSNP: rs7795743
rs7795743
EGFR ; EGFR-AS1
0.010 GeneticVariation BEFREE The G allele in rs7795743 in EGFR had an OR for metastasis of 0.68 (p-value = 0.02) and hazard ratio (HR) for progression of 0.66 (p-value = 0.004). 30827726

2019