|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Orthotopic implantation of PDCs carrying the activated Kras(G12D)-allele and shRNA against p16(Ink4a) or Trp53 resulted in tumor growth, metastasis, and reduced survival of NSG mice.
|
25724428 |
2015 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Further, in order to investigate whether IL-6 deletion contributes to suppression of lung cancer metastasis, we generated Kras(G12D); p53(flox/flox); IL-6(-/-) mice, which developed lung cancer with a trend for reduced metastases and longer survival than Kras(G12D); p53(flox/flox) mice.
|
24260500 |
2013 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Latency was shortened by combining Kras(G12D) activation with heterozygous or homozygous deletion of p53 (mean survival of 56 weeks vs. 19 weeks, respectively), which also resulted in widespread local and distant metastasis.
|
22266220 |
2012 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In summary, by using 'knock-in' mutations of Trp53 we have identified two critical acquired functions of a stably expressed mutant form of p53 that drive PDAC; first, an escape from Kras(G12D)-induced senescence/growth arrest and second, the promotion of metastasis.
|
20018721 |
2010 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190).
|
25027116 |
2014 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) genes may contribute to susceptibility to childhood ALL because they affect some important processes, such as metastasis regulation and tumor suppression.
|
23653000 |
2013 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
rs28934576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Together, these results reveal an important role for DLX2-NRP2 in p53-R273H</span>-induced cell mobility and tumor metastasis.
|
28796261 |
2017 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190).
|
25027116 |
2014 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190).
|
25027116 |
2014 |
|
rs121912664
|
|
|
0.020 |
GeneticVariation |
BEFREE |
DNA from intra-surgical specimens revealed a TP53 mutation at codon 337 (p.R337H) in samples with neoplastic cells (dysplasia, tumor and metastasis) but not in non-transformed cells (incomplete intestinal metaplasia and non-involved celiac lymph node).
|
22004116 |
2011 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
rs28934576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Taken together, these results suggest that transdominance of R273H mutant over wt p53 rather than a gain-of-function promotes tumor metastasis by increasing invasion and migration in HHUA cells.
|
17636407 |
2007 |
|
rs121912664
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the 19 patients with the Arg337His mutation, only one boy and three adults showed fatal evolution or recurrent metastases.
|
11600572 |
2001 |
|
rs1057519975
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The objective of the study was to check whether a polymorphism in the RAD51 gene (135 G>C), Ku70 protein expression, and tumor microenvironment: proliferation rate measured by BrdUrdLI and Ki-67LI, hypoxia (glucose transporter-1 expression), P53 protein expression, and DNA ploidy can influence DNA repair capacity, the factors contributing to patient overall survival (OS) and the incidence of recurrences and metastases.
|
30289394 |
2019 |
|
rs1131691036
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The objective of the study was to check whether a polymorphism in the RAD51 gene (135 G>C), Ku70 protein expression, and tumor microenvironment: proliferation rate measured by BrdUrdLI and Ki-67LI, hypoxia (glucose transporter-1 expression), P53 protein expression, and DNA ploidy can influence DNA repair capacity, the factors contributing to patient overall survival (OS) and the incidence of recurrences and metastases.
|
30289394 |
2019 |
|
rs730882002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The primary tumor and all the available metastases exhibited the same molecular oncogenic markers (namely, the RAS mutation p.Q61R and the telomerase promoter mutation C228T).
|
28781658 |
2017 |
|
rs760043106
|
|
|
0.010 |
GeneticVariation |
BEFREE |
P.I157T was not associated with increased risk of early death, breast cancer-associated death or distant metastasis relapse, and there was a significant difference in prognosis associated with the two CHEK2 mutations, p.I157T and c.1100delC.
|
27716369 |
2016 |
|
rs1800372
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a novel association between a TP53 rare variant and metastasis at diagnosis of osteosarcoma (rs1800372, odds ratio = 4.27, 95% confidence interval = 1.2 to 15.5, P = .026).
|
25896519 |
2015 |
|
rs121912651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The published mutp53 knock-in (KI) alleles (R172H, R270H, R248W) manifest GOF by broader tumor spectrum and more metastasis compared with the p53-null allele, but do not shorten survival.
|
23538418 |
2013 |
|
rs867114783
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One mutation each, involving a G-->T transversion in codon 215 in exon 6 (Ser-->lle) and a G-->A transition in codon 373 in exon 8 (Arg-->His), was identified in the remaining two secondary tumors.
|
10426802 |
1999 |