rs28934578
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Ectopic expression of this truncated domain significantly suppressed G1/S-phase transition, cellular proliferation, and tumour formation of RK3E-p53(R175H) /Rsf-1/cyclin E1 cells.
|
23378270 |
2013 |
rs28934578
|
|
|
0.780 |
GeneticVariation |
BEFREE |
In addition, exogenous Δ40p53 expression significantly suppressed cell growth in HCC cells with wild-type TP53, and in those that were mutant or null for TP53 Notably, Δ40p53α-induced tumor suppressor activity was markedly attenuated in cells expressing the hot-spot mutant Δ40p53α-R175H, which lacks the transcription factor activity of p53.
|
27980070 |
2017 |
rs28934578
|
|
|
0.780 |
GeneticVariation |
BEFREE |
In vitro, the R175L mutant displayed an attenuated tumor suppressor activity in the regulation of transcription, colony formation, and apoptosis when compared with wild-type p53 and the R175H mutant.
|
16707427 |
2006 |
rs28934578
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Moreover, R175H gain-of-function mutant expands the mammary epithelial stem cells (MESCs) that give rise to the mammary tumors.
|
22824795 |
2013 |
rs28934578
|
|
T |
0.780 |
GeneticVariation |
CLINVAR |
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
|
18391940 |
2008 |
rs28934578
|
|
T |
0.780 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs28934578
|
|
T |
0.780 |
GeneticVariation |
CLINVAR |
Role of the p53-homologue p73 in E2F1-induced apoptosis.
|
11101847 |
2000 |
rs28934578
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Since tumor cells face glucose and growth factor shortage when growing distant from sites of vascularization, we used genetically-matched human C8161 melanoma harbouring wt p53 or a tumor-associated (DN) mutant p53 (R175H), to investigate whether this mutation influences survival under metabolic stress.
|
21832879 |
2011 |
rs28934578
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Targeted next-generation sequencing with ThyroSeq v2 was performed on the tumor, and only a TP53 mutation (TP53 p.R175H) was identified.
|
26744121 |
2016 |
rs28934578
|
|
|
0.780 |
GeneticVariation |
BEFREE |
These findings suggest that TP53 somatic mutations, particularly at codon p.R175H, are enriched in tumors with infiltrating immune cells.
|
31637877 |
2019 |
rs28934578
|
|
|
0.780 |
GeneticVariation |
BEFREE |
To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in human tumors by homologous recombination.
|
10760284 |
2000 |