rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that polymorphism Arg72Pro in tumor suppressor gene TP53 increases the risk of lung cancer.
|
18336951 |
2008 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently a polymorphism at codon 72 (R72P) in the tumour suppressor gene TP53 has been implicated in the age of disease onset in HNPCC.
|
16353134 |
2006 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence of such an effect on survival within the TP53-mutated tumor group for TP53 R72P carriers but a suggestion of an effect for MDM2 SNP309 carriers (GG vs. TT-genotype HR 2.99, P = 0.06).
|
21667122 |
2011 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We identified the presence of LOH at 17p13 and Pro72Arg polymorphism in tumor DNA.
|
12684657 |
2003 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, we showed that BC patients with rs1042522 CC genotype were characterized by only unifocal tumors and decreased frequency of lymph node metastases (p=0.03).
|
21810023 |
2011 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNP) in codon Arg72Pro of P53 results in impairment of the tumor suppressor activity of the gene.
|
23167335 |
2012 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor Breslow thickness.
|
20535124 |
2010 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The analyses indicate that MDM2 SNP309 serves as a tumor susceptibility marker, and that there is an association between MDM2 SNP309 and p53 Arg72Pro regarding tumor susceptibility.
|
21619694 |
2011 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the association of a polymorphism in codon 72 of the p53 tumour suppressor gene (rs1042522) with cervical neoplasia have inconsistent results.
|
23441193 |
2013 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In recent years, a new physiological role in human fertility regulation has emerged for the tumor- suppressor p53 gene (P53), and the P53 Arg72Pro polymorphism has been associated with recurrent implantation failure in humans.
|
22532853 |
2012 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, we also found that the TP53 R72P polymorphism was not linked to tumor histologic type, histologic grade, lymph node metastases, and tumor size.
|
20193851 |
2010 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several previous studies evaluated the association between the Arg72Pro (rs1042522) polymorphism in the TP53 tumor suppressor gene and colorectal cancer (CRC).However, the results are conflicting.
|
27901479 |
2017 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to detect TP53 Arg72Pro polymorphism in postmenopausal patients with endometrial cancer (EC), to evaluate the risk of EC connected with it, as well to check for possible relationships with staging, grading and some risk factors of this neoplasm.
|
24379271 |
2013 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results indicate a remarkable application of R72P genotyping in the clinical setting: refine patient subclassification to identify those with an adverse clinical course despite tumour free lymph node status.
|
29286914 |
2018 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Specifically, two polymorphisms in p53, c.97-147ins16bp and p.Arg72Pro have been analysed as putative breast cancer susceptibility variants, and it has been recently reported that a p53 haplotype combining the absence of the 16-bp insertion and the presence of proline at codon 72 (No Ins-72Pro) was associated with an earlier age at the onset of the first primary tumour in BRCA2 mutation carriers in the Spanish population.
|
18781154 |
2008 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the possible association between the codon 72 polymorphism (Pro72Arg, rs1042522) of the tumor suppressor gene (TP53) and the presence of coronary artery disease (CAD) in Chilean subjects.
|
21252575 |
2011 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Arg72Pro genotype has no significant effects in patients with TP53 mutated tumors, in which p53 is non-functional.
|
23071787 |
2012 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this hospital-based case-control study, four potentially functional single-nucleotide polymorphisms -1628 G>A (rs1591420), -606 T>C [rs4978620, in complete linkage disequilibrium with -249T>C (rs2012775) and -122 G>A(rs2012566)], c.179 C>T p.Ala60Val (rs2269700) and 3' untranslated region-rs3750505 as well as the TP53 tumor suppressor gene codon 72 (Arg72Pro, rs1042522) polymorphism were genotyped in 1111 non-Hispanic Whites SCCHN patients and 1130 age-and sex-matched cancer-free controls.
|
20935061 |
2010 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The HPV E6 oncoprotein binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of p53 Arg72Pro polymorphism binds more ardently with HPV E6 than the Pro variant.
|
23065429 |
2012 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms were identified within the TP53 (R72P and Ins16) and MDM2 (SNP309) genes that may further diminish TP53 tumor suppressor activity.
|
19046423 |
2008 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene p53 at codon 72 (p53 R72P) differentially affects the responses to genotoxic insult.
|
28594296 |
2017 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There have been inconsistent reports regarding increased risk of POAG and a polymorphism (Arg72Pro) within the tumor suppressor gene, p53.
|
19784392 |
2009 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TP53 R72P polymorphism was not linked to tumor location, histologic grade, lymph node metastases, Dukes stage, p53 positivity, or age at diagnosis, but to tumor size.
|
17599946 |
2007 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, we also found that the TP53 R72P polymorphism was not linked to tumor histologic type, histologic grade, lymph node metastases, and tumor size.
|
20193851 |
2010 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to detect TP53 Arg72Pro polymorphism in postmenopausal patients with endometrial cancer (EC), to evaluate the risk of EC connected with it, as well to check for possible relationships with staging, grading and some risk factors of this neoplasm.
|
24379271 |
2013 |