|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Thirty percent of HCCs harbored TERT promoter mutations and there was a significant difference in rs2736098 and rs2736100 genotypes between wt and mutant TERT promoter-bearing HCC tumors (P = 0.007 and 0.018, respectively).
|
28416747 |
2017 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our research seems to provide strong evidence for an association between CLPTM1L rs402710C/T and TERT rs2736100A/C SNPs and the risk of OSSC, and suggests that higher tumor RTL values and positive hTERT expression may be applicable as early prognostic markers.(J Oral Sci 58, 449-458, 2016).
|
28025427 |
2016 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Meanwhile, rs2736100 was significantly associated with TERT mRNA expression in both normal and tumor lung tissues.
|
26149460 |
2015 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Adjusting for tumor grade showed a significant association between rs2736100 and IDH status (P = .01), 10q loss (P = .02); rs4295627 and 1p-19q codeletion (P = .04), rs498872 and IDH (P = .02), 9p loss (P = .04), and 10q loss (P = .02).
|
23161787 |
2013 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
For lung cancer, which was the most studied tumor type, the estimated joint population attributable risk for three polymorphisms (TERT rs2736100, intergenic rs4635969, and CLPTM1L rs402710) was 41%.
|
22523397 |
2012 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies.
|
22886559 |
2012 |
|
rs2736100
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In both cohorts, the frequencies of rs2736100 and rs6010620 risk genotypes were highly correlated with high-grade disease (P < 0.001), whereas rs4295627 and rs498872 risk genotypes were inversely related to tumor grade (P < 0.001).
|
20847058 |
2010 |
|
rs2853669
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The TERT core promoter region containing the previously described mutations and a common functional polymorphism (rs2853669) was sequenced in tumors and blood samples from 192 GBM patients.
|
25140036 |
2015 |
|
rs2853669
|
|
|
0.030 |
GeneticVariation |
BEFREE |
TERT rs2853669 polymorphism was found in 44.4% of tumors.
|
25448848 |
2015 |
|
rs2853669
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Interleukin-6 (IL-6) expression regulated by TERT promoter status and polymorphism, what leads us to think that TERT and IL-6 plays a significant role in GBM, where specific SNPs increase the risk of developing GBM while the rs2853669 SNP and specific mutations in the TERT promoter of the tumor lead to shorter survival.
|
26143636 |
2015 |
|
rs2736098
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The population with the TERT rs2736098 locus carrying the mutant genotype (CT+TT) was associated with the number of tumors (OR=0.553, 95% CI=0.236-0.928).
|
28789383 |
2017 |
|
rs2736098
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thirty percent of HCCs harbored TERT promoter mutations and there was a significant difference in rs2736098 and rs2736100 genotypes between wt and mutant TERT promoter-bearing HCC tumors (P = 0.007 and 0.018, respectively).
|
28416747 |
2017 |
|
rs10069690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification according to age, T stage, tumor size and tumor node metastasis (TNM) stage, the distribution frequencies of CC genotype and CT + TT genotype of rs10069690C/T showed significant difference (P < 0.05).
|
27472887 |
2016 |
|
rs2075786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, MMR gene mutation carriers with hTERT rs2075786 are at high risk to develop a LS-related tumor at an early age.
|
22948024 |
2013 |
|
rs2735940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Most notable were associations with TERT rs2736118 (ORadj 6.18, 95% CI 2.90, 13.19) with estrogen receptor negative/progesterone receptor positive (ER-/PR+) tumors and TERT rs2735940 (ORadj 0.73, 95% CI 0.59, 0.91) with ER-/PR- tumors.
|
23629941 |
2013 |
|
rs2736118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Most notable were associations with TERT rs2736118 (ORadj 6.18, 95% CI 2.90, 13.19) with estrogen receptor negative/progesterone receptor positive (ER-/PR+) tumors and TERT rs2735940 (ORadj 0.73, 95% CI 0.59, 0.91) with ER-/PR- tumors.
|
23629941 |
2013 |