Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Molecular characterization and clinical interpretation of BRCA1/BRCA2 variants in families from Murcia (south-eastern Spain) with hereditary breast and ovarian cancer: clinical-pathological features in BRCA carriers and non-carriers. 28477318

2017

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients. 28724667

2017

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR OLA1 gene sequencing in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer. 27271530

2017

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Naturally occurring BRCA2 alternative mRNA splicing events in clinically relevant samples. 27060066

2016

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients. 26848529

2016

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Breast cancer in a male-to-female transsexual patient with a BRCA2 mutation. 27000661

2016

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Development and Validation of a Next-Generation Sequencing Assay for BRCA1 and BRCA2 Variants for the Clinical Laboratory. 26295337

2015

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Prevalence and differentiation of hereditary breast and ovarian cancers in Japan. 24249303

2015

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Prevalence of BRCA1 mutations and responses to neoadjuvant chemotherapy among BRCA1 carriers and non-carriers with triple-negative breast cancer. 25480878

2015

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR BRCA1 and BRCA2 mutations in males with familial breast and ovarian cancer syndrome. Results of a Spanish multicenter study. 26026974

2015

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR New recurrent BRCA1/2 mutations in Polish patients with familial breast/ovarian cancer detected by next generation sequencing. 25948282

2015

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Next-generation sequencing of the BRCA1 and BRCA2 genes for the genetic diagnostics of hereditary breast and/or ovarian cancer. 25556971

2015

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Functional classification of BRCA2 DNA variants by splicing assays in a large minigene with 9 exons. 25382762

2015

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Central European BRCA2 mutation carriers: birth cohort status correlates with onset of breast cancer. 24156927

2014

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Comparative in vitro and in silico analyses of variants in splicing regions of BRCA1 and BRCA2 genes and characterization of novel pathogenic mutations. 23451180

2013

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families. 22923021

2012

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation. 22340495

2012

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Comprehensive splicing functional analysis of DNA variants of the BRCA2 gene by hybrid minigenes. 22632462

2012

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer. 22798144

2012

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Guidelines for splicing analysis in molecular diagnosis derived from a set of 327 combined in silico/in vitro studies on BRCA1 and BRCA2 variants. 22505045

2012

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Spectra of BRCA1 and BRCA2 mutations in Korean patients with breast cancer: the importance of whole-gene sequencing. 22217648

2012

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer. 23035815

2012

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR A review of a multifactorial probability-based model for classification of BRCA1 and BRCA2 variants of uncertain significance (VUS). 21990134

2012

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer. 21324516

2011

dbSNP: rs28897756
rs28897756
A 0.700 CausalMutation CLINVAR A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes. 21702907

2011