|
rs1423753702
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We report on a novel WT1 nonsense mutation (c.1105C>T), introducing a premature stop codon in exon 8 (p.Q369X), in a young XY male patient who presented with bilateral cryptorchidism, nystagmus, mild proteinuria and WT, but no sign of severe nephropathy.
|
19048299 |
2009 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
SNP in the WT1 gene (rs16754) was significantly associated with lower expression of WT1.
|
30082223 |
2018 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, WT1 rs16754 polymorphism is associated with better survival of AML.
|
26992216 |
2016 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genetic variant rs16754 of Wilms tumor gene 1 (WT1) has recently been described as an independent prognostic factor in AML patients.
|
25932444 |
2015 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The high prevalence of WT1 SNP rs16754, and its correlation with improved outcome, identifies WT1 SNP rs16754 as a potentially important molecular marker of prognosis in pediatric AML.
|
21189390 |
2011 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of WT1 mutation in the Southeast Asian AML was thus comparable to the figures reported from the West although the designated major allele for rs16754 polymorphism was different.
|
21798259 |
2011 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
At least one copy of the minor SNP rs16754 allele (WT1(AG) or WT1(GG)) was detected in 30 (29 %) patients.
|
22895555 |
2012 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphism (SNP) within Wilms tumor-1 (WT1) exon 7, rs16754, has been arguably reported to be implicated in acute myeloid leukemia (AML) prognosis.
|
26499507 |
2016 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Wilms tumor gene single nucleotide polymorphism rs16754 predicts a favorable outcome in children with acute lymphoblastic leukemia.
|
26224397 |
2015 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
|
21659357 |
2011 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Wilms' tumour gene 1 (WT1) single nucleotide polymorphism (SNP) rs16754 has recently been described as an independent prognostic factor in acute myeloid leukaemia (AML) patients.
|
23484026 |
2013 |
|
rs16754
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The assay allows evaluating WT1 rs16754 polymorphism in diagnostic routine to improve prognostic information faster and without over-costing for diagnostic laboratories.
|
29407184 |
2018 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The effect of rs1042522 C>G polymorphism on Wilms tumor prevalence was analyzed using logistic regression models.
|
30610160 |
2019 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Overall, our result suggested a lack of association between the <i>TP53</i> gene Arg72Pro polymorphism and Wilms' tumor.
|
28260929 |
2017 |
|
rs11655237
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, we failed to find any association between the LINC00673 rs11655237 C>T polymorphism and WT risk.
|
31257678 |
2019 |
|
rs11655237
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These data could be useful for reinforcing our understanding of the potential contribution of LINC00673 rs11655237 C>T to Wilms tumor susceptibility.
|
31657076 |
2019 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.
|
25536437 |
2015 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Impact of the MTHFR C677T polymorphism on risk of Wilms tumor: case-control study.
|
19346876 |
2009 |
|
rs1037084691
|
|
|
0.010 |
GeneticVariation |
BEFREE |
WT1(R458Q) overexpression significantly downregulated nephrin and synaptopodin expression, promoted apoptosis in HEK293 cells and impaired focal contact formation in podocytes.
|
25145932 |
2015 |
|
rs1049509674
|
|
|
0.010 |
GeneticVariation |
BEFREE |
analysis of the Wilms' tumour suppressor gene in a patient with Frasier syndrome by the polymerase chain reaction and direct sequencing detected a + 5G -->A transition at a position of the second alternative splice region of exon 9, important for predicting the risk of the occurrence of Wilms' tumour.
|
11954756 |
2002 |
|
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.
|
25536437 |
2015 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations with Wilms tumor susceptibility were shown for hOGG1 rs1052133 (dominant: adjusted OR = 0.66, 95% CI = 0.45-0.96, P = .030), FEN1 rs174538 (dominant: adjusted OR = 0.66, 95% CI = 0.45-0.95, P = .027; recessive: adjusted OR = 0.54, 95% CI = 0.32-0.93 P = .027), and FEN1 rs4246215 (dominant: adjusted OR = 0.55, 95% CI = 0.38-0.80, P = .002) polymorphisms.
|
29937070 |
2018 |
|
rs1059111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between rs11994014 G>A or rs1059111 A>T polymorphisms and Wilms' tumor susceptibility did not reach statistical significance.
|
31057612 |
2019 |
|
rs10767935
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two-independent intronic genotyped SNPs (rs10767935 and rs5030244) in WT1 significantly modified the IFN-β-25(OH)D association after adjustment (P(interaction) = 0.001, 0.0002; P(adj) = 0.003, 0.006, respectively).
|
25312909 |
2015 |
|
rs10972727
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the G allele of rs11788747 in the RECK gene was significantly associated with WT in Chinese children (OR=0.7, 95% CI: 0.45-0.99; P=0.042); as with another SNP rs10972727, however, no statistically significant difference was detected.
|
26141647 |
2015 |