Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1206846668
rs1206846668
FOLH1
0.030 GeneticVariation BEFREE Maternal MTHFR C677T and parental GCP II C1561T polymorphisms are associated with increased risk for NTDs. 20047525

2010
dbSNP: rs1206846668
rs1206846668
FOLH1
0.030 GeneticVariation BEFREE The MTHFR 677C-->T polymorphism was shown to represent a risk factor in NTD cases (CC v CT+TT odds ratio (OR) 2.03 [95% confidence interval (CI) 1.09, 3.79] p = 0.025) and the MTRR 66A-->G polymorphism was shown to exert a protective effect in NTD cases (AA v AG+GG OR 0.31 [95% CI 0.10, 0.94] p = 0.04). 15060097

2004
dbSNP: rs1206846668
rs1206846668
FOLH1
0.030 GeneticVariation BEFREE In addition, the MTHFR 677C > T variant conferred a modest protective effect in SBO mothers and the total NTD mother group, but not in SBA mothers. 14616766

2003