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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Low maternal folate concentrations and maternal MTHFR C677T polymorphism are associated with an increased risk for neural tube defects in offspring: a case-control study among Pakistani case and control mothers.
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29222906 |
2019 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
MTHFR (C677T, A1298C) and MTRR A66G polymorphisms were found to be protector factors for NTD fetuses in the mother group.
|
31238314 |
2019 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Here, we report on 3 men with hyperhomocysteinemia and the MTHFR C677T homozygous TT genotype that have reproductive histories of fetal NTDs.
|
30633186 |
2019 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T, but not A1298C, was associated with neural tube defects (OR, 1.24; 95% CI, 1.08-1.42) and Down syndrome (OR, 1.65; 95% CI, 1.39-1.95).
|
30474229 |
2019 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural tube defects.
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25788000 |
2015 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
We found no association between any of the fathers' genotypes and NTDs, whereas a significant correlation between MTHFR C677T polymorphism and NTD risk was found in NTD patients and in their mother.
|
25808073 |
2015 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Our study revealed that the SNPs of 677C > T and 1298A > C in MTHFR were associated with NTD-affected pregnancy, in which 677C > T was a risk factor and in contrast 1298A > C was protective factor against NTD.
|
25855017 |
2015 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
The interaction of COMT rs737865 and MTHFR C677T was associated with an increased risk of NTDs, especially anencephaly, in a Chinese population with a high prevalence of NTDs.
|
24990354 |
2015 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
However, in stratified analysis by geographical regions, we found that the maternal C677T polymorphism was significantly associated with the risk of NTD in Asian (OR(TvsC) = 1.43; 95% CI: 1.05-1.94), European (OR(TvsC) = 1.13; 95% CI: 1.04-1.24) and American (OR(TvsC) = 1.26; 95% CI: 1.13-1.41) populations.
|
25005003 |
2015 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
C677T mutation in methylenetetrahydrofolate reductase gene and neural tube defects: should Japanese women undergo gene screening before pregnancy?
|
24588777 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis strongly suggested a significant association of the variant MTHFR C677T and a suggestive association of RFC-1 A80G with increased risk of NTDs.
|
23593147 |
2013 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Haplotype tagging SNPs in the NOS genes were tested for genetic association with NTD subtypes, both for main effects as well as for the presence of interactions with the MTHFR C677T polymorphism.
|
24323870 |
2013 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
Interaction between maternal 5,10-methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene variants to increase the risk of fetal neural tube defects in a Shanxi Han population.
|
23489792 |
2013 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
The results suggested the maternal MTHFR C677T polymorphism is a genetic risk factor for NTDs.
|
23056169 |
2012 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
Gene variants in the folate metabolic pathway (e.g., MTHFR rs1801133 (677 C > T) and MTHFD1 rs2236225 (R653Q)) have been found to increase NTD risk.
|
22856873 |
2012 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The commonly associated maternal polymorphism 677C>T in the MTHFR gene did not predict risk of NTDs in the offspring (p > 0.05) and 1298A>C and 1781G>A polymorphisms in MTHFR were protective (p = 0.024 and 0.0004 respectively).
|
21770021 |
2011 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Although tHcy seems to be physiologically low in this Spanish population and unrelated to folate and B12 nutritional status, C677T MTHFR genotype, and some pregnancy complications, we support the statement that appropriate folate concentration may be important throughout pregnancy to prevent abnormalities associated with altered status (e.g., neural tube defects).
|
21367581 |
2011 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
C677T allele frequencies in NTD children and their mothers were similar to those found in controls.
|
20589617 |
2010 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
No significant associations between the C677T and A1298C MTHFR gene polymorphisms and NTDs and no differences between the two main ethnic groups (white-Caucasians, Roma) were found in Slovakia.
|
20672355 |
2010 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
The present study was conducted to evaluate the role of MTHFR 677 C-->T mutation as a risk factor for NTD in the South Indian population and to determine the relative importance of the genotypes in the affected child and its mother.
|
20887110 |
2010 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
A common polymorphism in the MTHFR gene (677C --> T) results in reduced enzymatic activity, and is associated with an increased risk for neural tube defects and cardiovascular disease.
|
19609317 |
2009 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate whether the cytosine-to-thymine mutation at base 677 of the methylenetetrahydrofolate reductase gene (MTHFR C677T), which has been associated with neural tube defects and congenital oral cleft, is also associated with tetralogy of Fallot (TF), a congenital heart disease.
|
19894660 |
2009 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
Folate deficiency and the presence of the 677C > T (CT) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene have been implicated in the causation of malformations in the fetus (particularly cleft lip and palate and neural tube defects).
|
17951123 |
2008 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the thermolabile variant of 5,10-methylene tetrahydrofolate reductase (C677T) has been suggested to be positively associated with the risk of vascular disease and neural tube defects.
|
17010581 |
2007 |