Gene: BARD1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6435862
rs6435862
BARD1
0.830 GeneticVariation BEFREE After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T). 31258718

2019
dbSNP: rs6435862
rs6435862
BARD1
0.830 GeneticVariation BEFREE However, stratified analysis showed a more profound association between neuroblastoma risk and rs6435862 TG/GG variant genotypes among older children (adjusted OR=1.55, 95% CI=1.04-2.31), and children with adrenal gland-originated disease (adjusted OR=2.94, 95% CI=1.40-6.18), or with ISSN clinical stages III+IV disease (adjusted OR=1.75, 95% CI=1.09-2.84). 26941572

2016
dbSNP: rs6435862
rs6435862
BARD1
0.830 GeneticVariation BEFREE All NB susceptibility genes replicated in the Italian dataset except for DDX4 and IL31RA, and the most significant SNP was rs6435862 in BARD1 (P = 8.4 × 10(-15)). 23222812

2013
dbSNP: rs6435862
rs6435862
BARD1
G 0.830 GeneticVariation GWASDB We also tested the two most significant SNPs (rs6435862, rs3768716) in two additional independent high-risk neuroblastoma case series, yielding combined allelic odds ratios of 1.68 each (P = 8.65 x 10(-18) and 2.74 x 10(-16), respectively). 19412175

2009
dbSNP: rs6435862
rs6435862
BARD1
G 0.830 GeneticVariation GWASCAT We also tested the two most significant SNPs (rs6435862, rs3768716) in two additional independent high-risk neuroblastoma case series, yielding combined allelic odds ratios of 1.68 each (P = 8.65 x 10(-18) and 2.74 x 10(-16), respectively). 19412175

2009
dbSNP: rs3768716
rs3768716
BARD1
0.820 GeneticVariation BEFREE After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T). 31258718

2019
dbSNP: rs3768716
rs3768716
BARD1
0.820 GeneticVariation BEFREE Our results suggest that the BARD1 rs6435862 T>G and rs3768716 A>G polymorphisms may contribute to increased susceptibility to neuroblastoma, especially for the subjects at age ≥12 months, with adrenal gland-originated or with late clinical stage neuroblastoma. 26941572

2016
dbSNP: rs3768716
rs3768716
BARD1
C 0.820 GeneticVariation GWASCAT Integrative genomics identifies LMO1 as a neuroblastoma oncogene. 21124317

2011
dbSNP: rs3768716
rs3768716
BARD1
C 0.820 GeneticVariation GWASDB Integrative genomics identifies LMO1 as a neuroblastoma oncogene. 21124317

2011
dbSNP: rs3768716
rs3768716
BARD1
0.820 GeneticVariation GWASDB We also tested the two most significant SNPs (rs6435862, rs3768716) in two additional independent high-risk neuroblastoma case series, yielding combined allelic odds ratios of 1.68 each (P = 8.65 x 10(-18) and 2.74 x 10(-16), respectively). 19412175

2009
dbSNP: rs17487792
rs17487792
BARD1
0.810 GeneticVariation BEFREE After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T). 31258718

2019
dbSNP: rs17487792
rs17487792
BARD1
T 0.810 GeneticVariation GWASCAT Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk. 28924153

2017
dbSNP: rs17487792
rs17487792
BARD1
0.810 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs7587476
rs7587476
BARD1
T 0.800 GeneticVariation GWASDB Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. 22941191

2012
dbSNP: rs7587476
rs7587476
BARD1
T 0.800 GeneticVariation GWASCAT Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. 22941191

2012
dbSNP: rs7587476
rs7587476
BARD1
0.800 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs10932572
rs10932572
BARD1
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs1374230
rs1374230
BARD1
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs16852600
rs16852600
BARD1
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs2053710
rs2053710
BARD1
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs6712055
rs6712055
BARD1
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs6715570
rs6715570
BARD1 ; SNHG31
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs7557557
rs7557557
BARD1
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs7584646
rs7584646
BARD1
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009
dbSNP: rs895459
rs895459
BARD1
0.700 GeneticVariation GWASDB Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. 19412175

2009