|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, mutation analyses performed in parallel in melanocytic nevi of the eyelid identified BRAF V600E alterations in all 3 cases.
|
29406329 |
2019 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BRAF V600E (c.1799T>A or c.1799_1800delTGinsA) and BRAF V600K mutations were detected in 85% (n = 34/40) of naevi.
|
28714107 |
2018 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Improving classification of melanocytic nevi: Association of BRAF V600E expression with distinct histomorphologic features.
|
29653212 |
2018 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We provided genetic evidence that Mitf E318K enhances BRaf V600E -induced nevus formation in vivo (mean nevus number for Mitf E318K , BRaf V600E vs Mitf WT , BRaf V600E , 68 vs 44, difference = 24, 95% CI = 9.1 to 38.9, P = .006).
|
28376192 |
2017 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, the frequency of BRAF V600E mutation was evaluated in Russian patients with melanocytic lesions, of which 41.25% were primary melanoma and 60% were melanocytic nevi.
|
25888143 |
2015 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine cases presented concomitant BRAF and NRAS mutations, including one case in which both the melanoma and the adjacent naevus harboured V600E and Q61K double mutations.
|
25857817 |
2015 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The absence of the BRAF V600E mutation within a changing naevus supports the theory that BRAFi stimulates the proliferation of wild-type BRAF cells.
|
25380183 |
2015 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E expression was detected in 11 of 12 globular naevi vs. four of 13 reticular naevi (91·7% vs. 30·1%, P = 0·004).
|
25039578 |
2014 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant association between BRAF(V600E) mutation and sex, histologic type, the Clark level, the Breslow index, solar elastosis, angiolymphatic and perineural invasion, satellitosis, and coexisting nevus.
|
24471189 |
2014 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BRAF-V600E status of confirmed new primary melanoma and dysplastic naevi was tested using a genetic mutation assay and immunohistochemistry.
|
24531394 |
2014 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Of the primary melanomas with an associated naevus (n = 29), 55% were BRAF(V600</span>E) mutant with 100% concordance between the melanoma and associated naevus.
|
24614711 |
2014 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found BRAF(V600E) mutations in the melanocytic nevi to be fully clonal, strongly suggesting that BRAF-activating mutations typically are early initiating events in melanocytic neoplasia.
|
23690527 |
2013 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF(V600E) mutations are also present in benign melanocytic naevi, highlighting the importance of additional genetic alterations in the genesis of malignant tumours.
|
21430779 |
2011 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In all, 59.8% cases of MN harbored BRAF exon T1799A mutation.
|
21326296 |
2011 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To ascertain the frequency of BRAF V600E mutations in AGN compared with banal naevi without atypia.
|
19919630 |
2010 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, using immunomagnetic separation or laser-capture microdissection, we examined BRAF mutations in sets of approximately 50 single cells isolated from acquired melanocytic nevi from 13 patients and found a substantial number of nevus cells that contained wild-type BRAF mixed with nevus cells that contained BRAF(V600E).
|
19752400 |
2009 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The V600E mutation was found in 0 (0%) of 13 samples diagnosed histologically as Spitz nevi, 9 (24.3%) of 37 invasive melanomas, and 5 (100%) of 5 other melanocytic nevi.
|
17824790 |
2007 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Differential gene expression in melanocytic nevi with the V600E BRAF mutation.
|
17696195 |
2007 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate whether the frequency of the BRAF(V600E) (V-raf murine sarcoma virus oncogene homolog B1) mutation in melanocytic nevi is associated with sun exposure patterns, we examined 120 acquired melanocytic nevi excised from various anatomic sites, including glabrous skin, as well as 62 congenital nevi.
|
16691193 |
2006 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This raises the question of whether naevi undergo BRAF(V600E)-induced senescence.
|
16079850 |
2005 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The predominant BRAF mutation T1799A (V600E) was detected in 18 nevi; 1 nevus had a novel A1781G (D594V) mutation in the same gene and 3 nevi had mutations in codon 61 of the N-ras gene.
|
15009715 |
2004 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 13 lesions with structural changes, BRAF(V599E) mutations were found in 4 (3 melanomas and 1 nevus).
|
15373778 |
2004 |