Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD. 29993116

2018

dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence. 23604333

2013

dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown. 22441734

2012

dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE These data confirm the effect of rs1051730 on nicotine dependence but failed to find any relationship with difficulty, willingness, and motivation to quit. 21511889

2011

dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE Genotypes for two SNPs in the CHRNA3/5 region (rs8034191, rs1051730) previously associated with nicotine dependence and COPD were analyzed for association to COPD and nicotine dependence phenotypes. 21232152

2011

dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group. 21747048

2011

dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE Using a cutoff point for the FTND score, the CHRNA3 Tyr215Tyr (rs1051730) polymorphism was also associated with nicotine dependence (p = 0.037 and p = 0.074 after correction for multiple testing). 20712524

2010

dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been associated with nicotine dependence, smoking intensity and lung cancer risk. 19247474

2009

dbSNP: rs1051730
rs1051730
0.790 GeneticVariation BEFREE A recent genome-wide association study demonstrated an association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence. 19429911

2009

dbSNP: rs1051730
rs1051730
T 0.790 GeneticVariation GWASDB A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. 18385739

2008