|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD.
|
29993116 |
2018 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence.
|
23604333 |
2013 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown.
|
22441734 |
2012 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
These data confirm the effect of rs1051730 on nicotine dependence but failed to find any relationship with difficulty, willingness, and motivation to quit.
|
21511889 |
2011 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Genotypes for two SNPs in the CHRNA3/5 region (rs8034191, rs1051730) previously associated with nicotine dependence and COPD were analyzed for association to COPD and nicotine dependence phenotypes.
|
21232152 |
2011 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group.
|
21747048 |
2011 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Using a cutoff point for the FTND score, the CHRNA3 Tyr215Tyr (rs1051730) polymorphism was also associated with nicotine dependence (p = 0.037 and p = 0.074 after correction for multiple testing).
|
20712524 |
2010 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been associated with nicotine dependence, smoking intensity and lung cancer risk.
|
19247474 |
2009 |
|
rs1051730
|
|
|
0.790 |
GeneticVariation |
BEFREE |
A recent genome-wide association study demonstrated an association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence.
|
19429911 |
2009 |
|
rs1051730
|
|
T |
0.790 |
GeneticVariation |
GWASDB |
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
|
18385739 |
2008 |
|
rs1451240
|
|
|
0.710 |
GeneticVariation |
GWASDB |
The genetic locus most strongly associated with nicotine dependence was rs1451240 on chromosome 8 in the region of CHRNB3 [odds ratio (OR) = 0.65, P = 2.4 × 10(-8) ].
|
22524403 |
2012 |
|
rs1451240
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The genetic locus most strongly associated with nicotine dependence was rs1451240 on chromosome 8 in the region of CHRNB3 [odds ratio (OR) = 0.65, P = 2.4 × 10(-8) ].
|
22524403 |
2012 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human α5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependence.
|
29573323 |
2018 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was a trend towards significance between rs16969968 and smoking behavior (smoking status [P = 0.05], nicotine dependence [AA > AG > GG; P = 0.08]).
|
29688464 |
2018 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD.
|
29993116 |
2018 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess its impact, we regressed the lifetime FTND latent variable on well-established factors associated with nicotine dependence (quitting smoking and the nicotinic acetylcholine receptor gene [CHRNA5] variant rs16969968, separately), and we observed that the regression coefficients were unchanged between models with and without adjustment for measurement non-invariance.
|
29438887 |
2018 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results indicate rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk.
|
30453884 |
2018 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype/diplotype analysis of rs880395 and rs1948 plus rs16969968 (a nonsynonymous CHRNA5 risk variant) in GWAS (COGEND, UW-TTURC, SAGE) yields a nicotine dependence risk profile only partially captured by rs16969968 alone.
|
27758088 |
2017 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian Population
|
29172281 |
2017 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies link a gene cluster encoding for α3β4α5-D398N nicotinic acetylcholine receptors to lung cancer risk as well as link a second mutation in this cluster to an increased risk for nicotine dependence.
|
28045487 |
2017 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans.
|
26239294 |
2016 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our top result was rs16969968 (P = 1.7 × 10(-14)) in CHRNA5, a locus previously associated with COPD susceptibility and nicotine dependence.
|
26771213 |
2016 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study showed a low to moderate level of ND in the Kashubians, influenced by age, sex, as well as the CHRNA5 rs16969968 variant.
|
25652844 |
2015 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype analyses showed that rs11636753-G and the functional rs16969968-A alleles together increased risk of nicotine dependence more than each variant alone: P = 3.1 × 10(-12), OR (95% CI) = 1.32 (1.22-1.43).
|
26220977 |
2015 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Minor allele carriers at rs16969968 in the nicotinic acetylcholine receptor α5 subunit gene (CHRNA5) have been shown to exhibit both reduced cognitive control and greater nicotine dependence.
|
24934182 |
2014 |