|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The FTO SNP (rs1421085) results in a T to C nucleotide substitution that may result in an increased risk for obesity in individuals who carry at least one C allele.
|
30124167 |
2018 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The FTO polymorphisms were associated with a significantly increased risk for obesity and in BMI-stratified cohort, rs9939609 (T/A: odds ratio [OR] = 1.73, p = 0.007) and rs1421085 (T/C: OR = 1.56, p = 0.03) showed even stronger association.
|
29466028 |
2018 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, we analyzed independent and combined effects of the FTO rs1421085 and MC4R rs17782313 risk alleles on BMI, fat mass, prevalence and incidence of obesity and subsequent type 2 diabetes (T2D) as well as their interactions with physical activity levels and gender in two European prospective population-based cohorts of 4,762 Finnish adolescents (NFBC 1986) and 3,167 French adults (D.E.S.I.R.).
|
19255736 |
2009 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
BACKGROUND The distribution of fat mass and obesity-associated gene (FTO) genes rs9939609 and rs1421085 in obese and normal ethnic Mongolians was analyzed to investigate the association of FTO gene polymorphisms with obesity and metabolic syndrome in ethnic Mongolians.
|
30442880 |
2018 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This indicates that the rs1421085-C allele in FTO induces obesity likely via other pathways than via reduced FatOx.
|
28626215 |
2017 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population.
|
21814223 |
2011 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In single locus analysis, FTO rs8050136 CA (p = 0.0001; OR (95% CI) = 2.4 (1.7-3.4) and AA (p = 0.0001; OR (95% CI) = 3.1 (1.9-5.2); FTO rs1421085 TA (p = 0.0001; OR (95% CI) = 2.1 (1.4-3.0) and AA (p = 0.0001; OR (95% CI) = 3.0 (1.8-5.0); FTO rs9939609 TC (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and CC (p = 0.0001; OR (95% CI) = 4.2 (2.5-7.3) along with TG (p = 0.001; OR (95% CI) = 2.1 (1.3-3.2) and GG (p = 0.021; OR (95% CI) = 3.8 (1.2-11.8) genotypes of FTO rs17817449 with GT (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and TT (p = 0.012; OR (95% CI) = 3.3 (1.8-3.6) genotypes of IRX3 rs3751723 were significantly associated with obesity.
|
26440677 |
2016 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The FTO rs1421085 T>C polymorphism may modulate the magnitude of dyslipidemia in Chinese early-onset obesity.
|
24331679 |
2014 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNPs rs1421085, rs17817449 and rs8043757 in the first intron of the FTO gene are associated with increasing risk of obesity in Thais.
|
25542809 |
2015 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation.
|
19153581 |
2009 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In African-Americans, only the rs1421085 C allele was a determinant of obesity risk (OR = 1.17, p = 0.05), but was found to be protective against diabetes (OR = 0.79, p = 0.03).
|
20502638 |
2010 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In case-control studies, both rs9939609 and rs1421085 polymorphisms were significantly associated with obesity (OR 1.97; 95% CI, 1.08-3.59; p = 0.026; OR 2.11; 95% CI, 1.17-3.81; p = 0.013, respectively) but not with overweight (p>0.05).
|
23342142 |
2013 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity.
|
17928949 |
2007 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
FTO genotypes associated with risk for obesity and loss of control of eating, specifically rs1421085, may interact with insecure attachment in a way that may exacerbate binge eating among women with BED.
|
30822753 |
2019 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene.
|
25074273 |
2014 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001)-an effect that persisted after adjustment for body weight (P = 0.004).
|
22513296 |
2012 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
FTO SNPs rs1421085</span> and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.
|
30537186 |
2019 |
|
rs1421085
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Significant associations were detected between obesity risk and the five polymorphisms: rs9939609 (OR: 1.31, 95% CI: 1.26 to 1.36), rs1421085 (OR: 1.43, 95% CI: 1.33 to 1.53), rs8050136 (OR: 1.25, 95% CI: 1.13 to 1.38), rs17817449 (OR: 1.54, 95% CI: 1.41 to 1.68), and rs1121980 (OR: 1.34, 95% CI: 1.10 to 1.62).
|
21651756 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation.
|
19153581 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m<sup>2</sup>) and tend to maintain a BMI > 35 kg/m<sup>2</sup> that characterize treatment failure.
|
28579220 |
2018 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In case-control studies of obesity defined by BMI, the minor C-allele of rs17782313 was associated with overweight/obesity and obesity (odds ratio [OR] 1.09, P = 0.006 and OR 1.12, P = 0.003, respectively).
|
19073769 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters in urban and rural dwelling Sri Lankans.
|
26948330 |
2016 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity.
|
30896429 |
2019 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Therefore, the present study aimed to examine the relationships between FTO rs9939609 and the MC4R rs17782313 with REE, leptin, ghrelin and thyrotropin levels in obe</span>se women.
|
24307561 |
2014 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data support that the rs9939609 and rs17782313 are strongly associated with obesity and BMI.
|
21063808 |
2011 |