Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation. 19153581

2009

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m<sup>2</sup>) and tend to maintain a BMI > 35 kg/m<sup>2</sup> that characterize treatment failure. 28579220

2018

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE In case-control studies of obesity defined by BMI, the minor C-allele of rs17782313 was associated with overweight/obesity and obesity (odds ratio [OR] 1.09, P = 0.006 and OR 1.12, P = 0.003, respectively). 19073769

2009

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters in urban and rural dwelling Sri Lankans. 26948330

2016

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity. 30896429

2019

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Therefore, the present study aimed to examine the relationships between FTO rs9939609 and the MC4R rs17782313 with REE, leptin, ghrelin and thyrotropin levels in obe</span>se women. 24307561

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Our data support that the rs9939609 and rs17782313 are strongly associated with obesity and BMI. 21063808

2011

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10⁻⁵, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10⁻⁶, 0.043, and 0.00085, respectively) in the Chinese children. 20843981

2010

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001). 22350153

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations. 19265794

2009

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect. 24151814

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians. 26226973

2016

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Our findings indicated that rs17782313, rs543874, rs2241423 and rs11084753 were associated with the risk for children obesity in China, and interaction of genetic variants with diet behaviors on obesity. 25637721

2015

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia. 25501231

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Impact of the Polymorphism Near <i>MC4R</i> (rs17782313) on Obesity- and Metabolic-Related Traits in Women Participating in an Aerobic Training Program. 28828082

2017

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE In addition, BDNF rs6265 and MC4R rs17782313 showed gender-dependent associations with decreased risk of having low HDL-C in males and increased risk of having abdominal obesity in females, respectively. 31502573

2019

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05). 22083549

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE The rs17782313 C allele is associated with eating behavior traits that may predispose obese children to increased energy intake and obesity. 27730429

2017

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels. 21372613

2011

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Genome-wide association studies have shown that variants near the melanocortin 4 receptor gene (MC4R) (rs17782313 and rs12970134) are associated with risk of obesity in Europeans. 22869321

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE The common polymorphism rs17782313 lying 188 kb downstream of the MC4R gene has recently been found to be unequivocally associated with body mass index (BMI) and obesity risk in adults and children. 20215774

2010

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Risk alleles for two obesity SNPs were associated with colorectal cancer risk--KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83-0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02-1.22; p = 0.02). 22511254

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE In conclusion, we could replicate the previously reported association between rs17782313 and complex obesity. 21303735

2011

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Melanocortin-4 receptor polymorphism rs17782313: association with obesity and eating in the absence of hunger in Chilean children. 24139164

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE We found correlation for two SNPs--rs11642015 and rs62048402 in the fat mass and obesity-associated protein (FTO) with obesity but no association was detected for rs17782313 located in the MC4R locus in these severely obese individuals. 24385306

2014