|
rs765019354
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel heterozygous nonsense variant in PCSK1 (p.Arg80*), encoding a propeptide truncated to less than two exons (out of 14), was found to co-segregate with obesity in a three-generation family.
|
24890885 |
2015 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity.
|
22737226 |
2012 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Coimmunoprecipitation of PC1/3-N222D and human PC1/3 variants associated with obesity with the endoplasmic reticulum (ER) chaperone BiP was studied in cell lines.
|
26786350 |
2016 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity.
|
20534142 |
2010 |
|
rs6235
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity.
|
20534142 |
2010 |
|
rs750845408
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity.
|
24890885 |
2015 |
|
rs6235
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, PCSK1 rs6235 risk allele was related to Adv36 seropositivity (chi(2)=6.85, p=0.033) in overweight/obese subgroup.
|
26680480 |
2015 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our data suggest that the PCSK1 rs6</span>232 and rs6235 SNPs are not major contributors to common obe</span>sity in the general population.
|
19528091 |
2009 |
|
rs6235
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our data suggest that the PCSK1 rs6232 and rs6235 SNPs are not major contributors to common obesity in the general population.
|
19528091 |
2009 |
|
rs6235
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group.
|
22737226 |
2012 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In RSPlus1, heterozygotes for rs6232 had 1.5 times higher risk of obesity (OR: 1.46; 95% confidence interval: 1.04-2.03; P=0.03).
|
25031086 |
2015 |
|
rs6234
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In this study, we found modest evidence for association of the PCSK1 rs6234 with BMI and overweight in men only but not in women, which suggested that PCSK1 rs6234 might not be an important contributor to obesity in Chinese Hans.
|
20498726 |
2010 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Increased energy intake and a more efficient metabolism contribute to the obesity in Pc1(N222D/N222D) mice.
|
16644867 |
2006 |
|
rs6234
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No difference was found in the association with different obesity grades, and no association of PCSK1 rs</span>6234-rs6235 with obesity was identified in Asian populations.
|
25355447 |
2014 |
|
rs6235
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No difference was found in the association with different obesity grades, and no association of PCSK1 rs6234-rs6235</span> with obesity was identified in Asian populations.
|
25355447 |
2014 |
|
rs155971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One SNP in the PCSK1 gene (rs155971) were nominally associated with risk of obesity in the SAPPHIRe cohort (P = 0.01).
|
19875984 |
2010 |
|
rs6235
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data revealed no association of PCSK1 rs6235 with the risk of obesity or overweight in the complete subjects.
|
24140494 |
2014 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant associations were found with binary obesity status for rs6232 (OR = 1.15, 95% CI 1.06-1.24, P = 6.08 × 10(-6)) and rs6234/rs6235 (OR = 1.07, 95% CI 1.04-1.10, P = 3.00 × 10(-7)).
|
25784503 |
2015 |
|
rs6234
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Significant associations were found with binary obesity status for rs6232 (OR = 1.15, 95% CI 1.06-1.24, P = 6.08 × 10(-6)) and rs6234/rs6235 (OR = 1.07, 95% CI 1.04-1.10, P = 3.00 × 10(-7)).
|
25784503 |
2015 |
|
rs6235
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant associations were found with binary obesity status for rs6232 (OR = 1.15, 95% CI 1.06-1.24, P = 6.08 × 10(-6)) and rs6234/rs6235 (OR = 1.07, 95% CI 1.04-1.10, P = 3.00 × 10(-7)).
|
25784503 |
2015 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, these data suggest that the increased obesity risk linked to the N221D allele in humans may be due in part to PC1/3-induced loss of resilience to stressors rather than strictly to decreased enzymatic activity on peptide precursors.
|
31504391 |
2019 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The effects of this novel variant on the biosynthesis, secretion, and catalytic activity were determined; the previously-described obesity risk SNPs N221D (rs6232), Q665E/S690T (rs6234/rs6235), and the Q665E and S690T SNPs (analyzed separately) were included for comparative purposes.
|
23383060 |
2013 |
|
rs6234
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The effects of this novel variant on the biosynthesis, secretion, and catalytic activity were determined; the previously-described obesity risk SNPs N221D (rs6232), Q665E/S690T (rs6234/rs6235), and the Q665E and S690T SNPs (analyzed separately) were included for comparative purposes.
|
23383060 |
2013 |
|
rs6232
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The nonsynonymous variants rs6232, encoding N221D, and rs6234-rs6235, encoding the Q665E-S690T pair, were consistently associated with obesity in adults and children (P = 7.27 x 10(-8) and P = 2.31 x 10(-12), respectively).
|
18604207 |
2008 |
|
rs6234
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The nonsynonymous variants rs6232, encoding N221D, and rs6234-rs6235, encoding the Q665E-S690T pair, were consistently associated with obesity in adults and children (P = 7.27 x 10(-8) and P = 2.31 x 10(-12), respectively).
|
18604207 |
2008 |