Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1421085
rs1421085
FTO
0.900 GeneticVariation BEFREE Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene. 25074273

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Therefore, the present study aimed to examine the relationships between FTO rs9939609 and the MC4R rs17782313 with REE, leptin, ghrelin and thyrotropin levels in obe</span>se women. 24307561

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect. 24151814

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia. 25501231

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Melanocortin-4 receptor polymorphism rs17782313: association with obesity and eating in the absence of hunger in Chilean children. 24139164

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE We found correlation for two SNPs--rs11642015 and rs62048402 in the fat mass and obesity-associated protein (FTO) with obesity but no association was detected for rs17782313 located in the MC4R locus in these severely obese individuals. 24385306

2014

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD. 24458218

2014

dbSNP: rs1421085
rs1421085
FTO
C 0.900 GeneticVariation GWASDB Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. 23563609

2013

dbSNP: rs1421085
rs1421085
FTO
C 0.900 GeneticVariation GWASCAT Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607

2013

dbSNP: rs1421085
rs1421085
FTO
C 0.900 GeneticVariation GWASCAT Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. 23563609

2013

dbSNP: rs1421085
rs1421085
FTO
0.900 GeneticVariation BEFREE In case-control studies, both rs9939609 and rs1421085 polymorphisms were significantly associated with obesity (OR 1.97; 95% CI, 1.08-3.59; p = 0.026; OR 2.11; 95% CI, 1.17-3.81; p = 0.013, respectively) but not with overweight (p>0.05). 23342142

2013

dbSNP: rs1421085
rs1421085
FTO
C 0.900 GeneticVariation GWASDB Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607

2013

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Genetic variants of the FTO gene rs9939609 A/T and the MC4R gene rs17782313 C/T have been associated with obesity. 23849767

2013

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Of 11 studied SNPs, four SNPs and genetic risk score (GRS) based on them were statistically significantly associated with central obesity by WC criteria (FTO rs9939609: OR = 1.29, 95%CI = 1.10-1.50, p = 0.001; MC4R rs17782313: OR = 1.27, 95%CI = 1.12-1.44, p = 1.32×10⁻⁴; GNPDA2 rs10938397: OR = 1.22, 95%CI = 1.09-1.37, p = 4.09×10⁻⁴; BDNF rs6265: OR = 1.20, 95%CI = 1.08-1.34, p = 8.86×10⁻⁴; GRS: OR = 1.25, 95%CI 1.16-1.34, p = 2.58×10⁻⁹) after adjustment for sex, age, pubertal stage, physical activity and family history of obesity. 23424664

2013

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents. 23447422

2013

dbSNP: rs1421085
rs1421085
FTO
0.900 GeneticVariation BEFREE Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001)-an effect that persisted after adjustment for body weight (P = 0.004). 22513296

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001). 22350153

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05). 22083549

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Genome-wide association studies have shown that variants near the melanocortin 4 receptor gene (MC4R) (rs17782313 and rs12970134) are associated with risk of obesity in Europeans. 22869321

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE Risk alleles for two obesity SNPs were associated with colorectal cancer risk--KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83-0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02-1.22; p = 0.02). 22511254

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE The results suggested that rs17782313 polymorphism was significantly associated with obesity risk (OR=1.18, 95%CI=1.15-1.21, p<0.001). 23049848

2012

dbSNP: rs17782313
rs17782313
0.900 GeneticVariation BEFREE We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India. 22421923

2012

dbSNP: rs8050136
rs8050136
FTO
0.900 GeneticVariation BEFREE Here we examined association of FTO variants (rs9939609 and rs8050136) with obesity and related anthropometric and biochemical traits in 3,126 Indian children (aged 11-17 years) including 2,230 normal-weight and 896 over-weight/obese children. 23091647

2012

dbSNP: rs1421085
rs1421085
FTO
0.900 GeneticVariation BEFREE However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population. 21814223

2011

dbSNP: rs1421085
rs1421085
FTO
0.900 GeneticVariation GWASDB Genome-wide population-based association study of extremely overweight young adults--the GOYA study. 21935397

2011