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rs1042713
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0.100 |
GeneticVariation |
BEFREE |
β2-adrenoceptor (β2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population.
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20738880 |
2010 |
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rs1042713
|
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0.100 |
GeneticVariation |
BEFREE |
Stratification analyses by obesity showed that A46G polymorphism was related to the prevalence of hypertension in the obese population (GG vs. AG vs. AA, P<0.001, OR = 1.645, 95%CI [1.258-2.151]).
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21483652 |
2011 |
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rs1042713
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0.100 |
GeneticVariation |
BEFREE |
Several case-control studies have explored the possible association between polymorphism in the beta2 adrenoreceptor gene (beta2AR), hypertension, and obesity--the focus being in particular on the Arg16Gly and Gln27Glu substitutions, which appear to modify the extracellular part of the beta2AR with possible functional modification.
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15323067 |
2004 |
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rs1042713
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0.100 |
GeneticVariation |
BEFREE |
The Arg16Gly genotype showed significant relationships to elevated central distribution of body fat and to systolic blood pressure, whilst the Glu27Glu genotype was associated with elevated leptin and triglyceride levels but not to other measurements, including obesity variables.
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10971791 |
2000 |
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rs1042713
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0.100 |
GeneticVariation |
BEFREE |
Although each polymorphism of β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood.
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21959333 |
2011 |
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rs1042713
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0.100 |
GeneticVariation |
BEFREE |
Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO<sub>2max</sub> , and ME.
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28294290 |
2017 |
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rs1042713
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0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
|
11016907 |
2000 |
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rs1042713
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0.100 |
GeneticVariation |
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
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rs1042713
|
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0.100 |
GeneticVariation |
BEFREE |
On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05).
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22731644 |
2012 |
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rs1042713
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0.100 |
GeneticVariation |
BEFREE |
Together, our findings suggest evidence for a two-locus interaction between the LEPR Gln223Arg and ADRB2 Arg16Gly variants in the risk of overweight/obesity, and highlight further the importance of multilocus effects in the genetic component of obesity.
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21233811 |
2011 |
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rs1042714
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0.100 |
GeneticVariation |
BEFREE |
Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism.
|
12888635 |
2003 |
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rs1042714
|
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0.100 |
GeneticVariation |
BEFREE |
We evaluated Gln27Glu polymorphism in the β2AR gene in obese Saudi populations to investigate the association of β2AR gene with obesity</span> and other related metabolic parameters.
|
20738880 |
2010 |
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rs1042714
|
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|
0.100 |
GeneticVariation |
BEFREE |
The Gln27Glu polymorphism was markedly associated with obesity with a relative risk for obesity of approximately 7 and an odds ratio of approximately 10.
|
9399946 |
1997 |
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rs1042714
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0.100 |
GeneticVariation |
BEFREE |
Our study indicates that the ADRB2 rs1042714 SNP may contribute to the risk of obesity and predict obesity-related metabolic traits such as BMI, triglyceride, and systolic blood pressure in Taiwanese subjects.
|
24322328 |
2014 |
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rs1042714
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0.100 |
GeneticVariation |
BEFREE |
The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity.
|
19186333 |
2008 |
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rs1042714
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
|
11016907 |
2000 |
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rs1042714
|
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|
0.100 |
GeneticVariation |
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |
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rs1042714
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0.100 |
GeneticVariation |
BEFREE |
Interactions were detected between ADRA2A C-1291G and ADRB2 Gln27-->Glu variants for obesity in African Americans and between ADRA2A C-1291G SNP and ADBR1 haplotype for obesity in whites.
|
17512307 |
2007 |
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rs1042714
|
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|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis revealed that the rs1042714 (Gln27Glu) polymorphism is associated with obesity susceptibility.
|
24960039 |
2014 |
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rs1042714
|
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|
0.100 |
GeneticVariation |
BEFREE |
Even in Japanese-Americans, who have a more westernized life style than Japanese, the association of the beta(2)-AR gene (Gln27Glu) variant with the parameters of obesity, insulin resistance, and serum lipid level has yet to be clarified.
|
11288039 |
2001 |
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rs1042714
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0.100 |
GeneticVariation |
BEFREE |
As there is a high prevalence of obesity in Tonga, we aimed to determine the distribution of the beta2 adrenoceptor gene Gln(27)Glu polymorphism and to assess its relevance to obesity and to Type II diabetes, known to be prevalent in that population.
|
12605574 |
2003 |
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rs1042714
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|
0.100 |
GeneticVariation |
BEFREE |
A total of 107 unrelated overweight/obese individuals were genotyped for two ADRB2 non-synonymous polymorphisms: Arg16Gly (rs1042713) and Gln27Glu (rs1042714).
|
29331538 |
2018 |
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rs1042714
|
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|
0.100 |
GeneticVariation |
BEFREE |
Gender is an effect modifier for the effect of the rs1042714 polymorphism on obesity-related traits in Malaysian Malays.
|
22199155 |
2015 |
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rs1042714
|
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|
0.100 |
GeneticVariation |
BEFREE |
These results provide evidence about a possible impact of the Gln27Glu polymorphism in the ADRB2 gene concerning a better response to exercise in obese Gln27 female subjects, in which basal insulinemia may play a role.
|
12435085 |
2002 |
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rs1042714
|
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|
0.100 |
GeneticVariation |
BEFREE |
The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females.
|
10205587 |
1999 |