|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs9939609 and rs17782313 are associated with PCOS and obesity-related traits and profiles.
|
26032905 |
2015 |
|
rs17782313
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
19151714 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.
|
18682847 |
2008 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results suggested that rs17782313 polymorphism was significantly associated with obesity risk (OR=1.18, 95%CI=1.15-1.21, p<0.001).
|
23049848 |
2012 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic variants of the FTO gene rs9939609 A/T and the MC4R gene rs17782313 C/T have been associated with obesity.
|
23849767 |
2013 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity.
|
21347432 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population.
|
21147891 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India.
|
22421923 |
2012 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
<i>Purpose</i>.Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (<i>MC4R</i>) gene and rs6265 near the brain-derived neurotrophic factor (<i>BDNF</i>) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children.
|
28396685 |
2017 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Of 11 studied SNPs, four SNPs and genetic risk score (GRS) based on them were statistically significantly associated with central obesity by WC criteria (FTO rs9939609: OR = 1.29, 95%CI = 1.10-1.50, p = 0.001; MC4R rs17782313: OR = 1.27, 95%CI = 1.12-1.44, p = 1.32×10⁻⁴; GNPDA2 rs10938397: OR = 1.22, 95%CI = 1.09-1.37, p = 4.09×10⁻⁴; BDNF rs6265: OR = 1.20, 95%CI = 1.08-1.34, p = 8.86×10⁻⁴; GRS: OR = 1.25, 95%CI 1.16-1.34, p = 2.58×10⁻⁹) after adjustment for sex, age, pubertal stage, physical activity and family history of obesity.
|
23424664 |
2013 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Most notably, the association between 5 SNPs (Fas apoptotic inhibitory molecule 2 rs7138803, Niemann-Pick disease, type C1 rs1805081, fat mass- and obesity-associated gene rs6499640, melanocortin 4 receptor gene rs17782313, and brain-derived neurotrophic factor rs6265) and obesity risk was only observed in children who had moderate-to-low physical activity levels or engaged in sedentary behavior, regardless of which risk alleles they carried.
|
21527513 |
2011 |
|
rs17782313
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
19151714 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.
|
24458218 |
2014 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR).
|
28090739 |
2017 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.
|
23447422 |
2013 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study pointed out the role of MC4R rs17782313 and ENPP1 rs1044498 genotypes in obesity determinisms in mothers and their newborns in correlation with BMI, MUAC, TST and bioimpedance parameters.
|
31350533 |
2019 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Here, we investigated the involvement of FTO rs9939609 and MC4R rs17782313 polymorphisms in the development of obesity.
|
19668254 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The MC4R rs17782313 C allele was more associated with obesity and fat mass deposition in males than in females (P = 0.003 and P = 0.03, respectively) and low physical activity accentuated the effect of the FTO polymorphism on BMI increase and obesity prevalence (P = 0.008 and P = 0.01, respectively).
|
19255736 |
2009 |