|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations.
|
19265794 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Risk alleles for two obesity SNPs were associated with colorectal cancer risk--KCTD15 rs29941 [odds ratio (OR) for C allele = 0.90, 95% confidence interval (CI) 0.83-0.98; p = 0.01] and MC4R rs17782313 (OR for C allele = 1.12, 95% CI 1.02-1.22; p = 0.02).
|
22511254 |
2012 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs9939609 and rs17782313 are associated with PCOS and obesity-related traits and profiles.
|
26032905 |
2015 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity.
|
21347432 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Six other SNPs, rs2815752 (NEGR1), rs10938397 (GNPDA2), rs10838738 (MTCH2), rs7498665 (SH2B1), rs17782313 (MC4R) and rs11084753 (KCTD15), were not associated with obesity (P>0.05).
|
22083549 |
2012 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs17782313 C allele is associated with eating behavior traits that may predispose obese children to increased energy intake and obesity.
|
27730429 |
2017 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The common polymorphism rs17782313 lying 188 kb downstream of the MC4R gene has recently been found to be unequivocally associated with body mass index (BMI) and obesity risk in adults and children.
|
20215774 |
2010 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The MC4R rs17782313 C allele was more associated with obesity and fat mass deposition in males than in females (P = 0.003 and P = 0.03, respectively) and low physical activity accentuated the effect of the FTO polymorphism on BMI increase and obesity prevalence (P = 0.008 and P = 0.01, respectively).
|
19255736 |
2009 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results suggested that rs17782313 polymorphism was significantly associated with obesity risk (OR=1.18, 95%CI=1.15-1.21, p<0.001).
|
23049848 |
2012 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Therefore, the present study aimed to examine the relationships between FTO rs9939609 and the MC4R rs17782313 with REE, leptin, ghrelin and thyrotropin levels in obe</span>se women.
|
24307561 |
2014 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR).
|
28090739 |
2017 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters in urban and rural dwelling Sri Lankans.
|
26948330 |
2016 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.
|
23447422 |
2013 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.
|
18682847 |
2008 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found correlation for two SNPs--rs11642015 and rs62048402 in the fat mass and obesity-associated protein (FTO) with obesity but no association was detected for rs17782313 located in the MC4R locus in these severely obese individuals.
|
24385306 |
2014 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional studies in the Chinese population.
|
21147891 |
2011 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India.
|
22421923 |
2012 |
|
rs17782313
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m<sup>2</sup>) and tend to maintain a BMI > 35 kg/m<sup>2</sup> that characterize treatment failure.
|
28579220 |
2018 |