|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To determine whether there are variations in leptin levels according to the beta(3)-adrenoceptor (beta(3)-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826A-->G polymorphisms, given the regulatory role of catecholamines through the beta(3)-AR in leptin production and the previously reported association of the UCP1 -3826A-->G variant with obesity.
|
15536594 |
2004 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results indicated that the ADRB3 Trp64Arg variant is not related to the development of GDM and has no effect on obesity during pregnancy in a Taiwanese population.
|
15334374 |
2004 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
An association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene and endometrial cancer and obesity.
|
15743038 |
2004 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of the beta(3)-receptor does not predispose to preeclampsia, and it is it not associated with obesity and carbohydrate intolerance in a population of young pregnant women.
|
15042014 |
2004 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro.
|
12965109 |
2003 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Although many studies have examined the relationship between the Trp(64)Arg mutation of ADRB3 and obesity, the results have been inconsistent.
|
14671190 |
2003 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The beta(3)-adrenergic receptor gene (BAR-3) allelic variant (Trp64Arg and Arg64Arg) is correlated with obesity or non-insulin-dependent diabetes mellitus.
|
12943691 |
2003 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.
|
12406043 |
2002 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We performed molecular scanning of the human type 2 deiodinase (DIO2) gene and evaluated a novel variant for associations with obesity and insulin resistance, assessing both the main effect and interaction with the Trp64Arg beta-3--adrenergic receptor (ADRB3) variant.
|
11872697 |
2002 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Individuals aged 20-35 years who are Trp64Arg carriers had a substantially higher risk of developing obesity, independent of their sex or leisure-time physical activity.
|
12169859 |
2002 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In summary, we found that obese postmenopausal women who carry the Trp64Arg variant in the beta(3)-adrenoceptor had similar changes in body composition and energy expenditure to noncarriers of the variant in response to prolonged caloric restriction.
|
12037740 |
2002 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We investigated gender differences in the relationships between the Trp64Arg variant of the beta(3)-adrenergic receptor (AR) gene in obesity and insulin resistance in nondiabetic subjects.
|
11532330 |
2001 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The beta(3)-adrenergic receptor (AR) gene variant (Trp64Arg) has been reported to be associated with obesity and insulin resistance in humans.
|
11288039 |
2001 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.
|
11522702 |
2001 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We found gender-specific associations between the Trp64Arg mutation and obesity related phenotypes.
|
11576322 |
2001 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Although other studies suggest that the W64R variant is associated with the development of obesity and insulin resistance, we cannot demonstrate that it has a major effect on BMI in children with premature pubarche or in adolescent girls with hyperandrogenism.
|
10689004 |
2000 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Heterozygosity for the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not accompanied by obesity, impaired glucose tolerance and type 2 diabetes mellitus in the general elderly Dutch population, and is also not associated with changes in circulating leptin levels.
|
9828912 |
1998 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.
|
9709965 |
1998 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We conclude that the Trp64Arg variant is associated with obesity in this Mexican American population.
|
9449691 |
1998 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients.
|
9405912 |
1997 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans.
|
9439659 |
1997 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Lack of association between the Trp64 Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis.
|
9100608 |
1997 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the TRP64ARG beta 3AR mutation or any other mutation in the beta 3AR gene is not a major contributor to genetic susceptibility to NIDDM and obesity likely in Nauruans.
|
8923875 |
1996 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The allelic frequency of Trp64Arg</span> was similar in obese and non-obese subjects (9.4 and 12.5%, respectively).
|
8817112 |
1996 |
|
rs4994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In SOS, the frequency of the Trp64Arg allele was not significantly different between nonobese and obese female subjects and no association was found between the mutation and body weight gain over time.
|
8903328 |
1996 |