Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1805094
rs1805094
0.080 GeneticVariation BEFREE Influence of K656N Polymorphism of the Leptin Receptor Gene on Obesity-Related Traits in Nondiabetic Afro-Caribbean Individuals. 30807250

2019

dbSNP: rs1805094
rs1805094
0.080 GeneticVariation BEFREE Effect of Lys656Asn Polymorphism of Leptin Receptor Gene on Cardiovascular Risk Factors and Serum Adipokine Levels after a High Polyunsaturated Fat Diet in Obese Patients. 25132099

2015

dbSNP: rs1805094
rs1805094
0.080 GeneticVariation BEFREE Taken together, our data suggest that a combination of polymorphism in the LEP gene 3' flanking region, and Lys109Arg, Lys656Asn variants in LEPR gene is associated with obesity in Chinese Han population. 24308887

2013

dbSNP: rs1805094
rs1805094
0.080 GeneticVariation BEFREE Lys656Asn polymorphism of LEPR gene is associated with obesity parameters, insulin resistance and glucose levels in patients with NAFLD. 22530350

2012

dbSNP: rs1805094
rs1805094
0.080 GeneticVariation BEFREE This study evaluated the association between obesity and the K109R, Q223R, and K656N polymorphisms of the leptin receptor (LEPR) locus. 22746211

2012

dbSNP: rs1805094
rs1805094
0.080 GeneticVariation BEFREE We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated subjects. 22028824

2011

dbSNP: rs1805094
rs1805094
0.080 GeneticVariation BEFREE Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity. 15972940

2005

dbSNP: rs1805094
rs1805094
0.080 GeneticVariation BEFREE These findings support the hypothesis that the Q223R polymorphism (but not the K109R or K656N polymorphism) of the leptin receptor gene is associated with obesity and predicts a small percentage of body weight and body composition variability in a genetically homogeneous population. 11549688

2001