|
rs200750564
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our meta-analysis showed that the MTHFR C677T mutation was a risk factor for male infertility in both azoospermia and oligoasthenoteratozoospermia patients, especially in Asian population.
|
26549413 |
2015 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Influence of methylenetetrahydrofolate reductase C677T gene polymorphisms in Algerian infertile men with azoospermia or severe oligozoospermia.
|
22928696 |
2012 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic infertile Brazilian patients with nonobstructive azoospermia (NOA) or severe oligozoospermia and fertile Brazilian men as controls to explore the possible association of these polymorphisms and male infertility.
|
21138341 |
2011 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia.
|
16888682 |
2007 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Pooled estimate on c.1298A>C data from all published studies including our data showed no association of this polymorphism with male infertility (Odds ratio = 1.035, P = 0.56), azoospermia (Odds ratio = 0.97, P = 0.74), or oligoasthenoteratozoospermia (Odds ratio = 0.92, p = 0.29).
|
23874907 |
2013 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, the homozygous (C/C) A1298C polymorphism of the MTHFR gene was present at a statistically high significance in severe oligozoospermia group compared with controls (OR = 3.372, 95% confidence interval CI = 1.27-8.238; p = 0.01431).
|
22457816 |
2012 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic infertile Brazilian patients with nonobstructive azoospermia (NOA) or severe oligozoospermia and fertile Brazilian men as controls to explore the possible association of these polymorphisms and male infertility.
|
21138341 |
2011 |
|
rs4647269
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs1800734 and rs4647269 in MLH1 were found to be significantly different between severe oligozoospermia and control groups (p < 0.05).
|
31342644 |
2019 |
|
rs12870438
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population.
|
28975488 |
2018 |
|
rs7174015
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population.
|
28975488 |
2018 |
|
rs12870438
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between rs7174015 and oligozoospermia under a dominant model and between rs12870438 and azoospermia under additive and recessive models remained after correction for multiple testing.
|
25908656 |
2015 |
|
rs7174015
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between rs7174015 and oligozoospermia under a dominant model and between rs12870438 and azoospermia under additive and recessive models remained after correction for multiple testing.
|
25908656 |
2015 |
|
rs2075789
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs4647269
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs6166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we have evaluated the response of FSH treatment in terms of sperm production on the basis of Ala307Thr-Asn680Ser polymorphisms in the FSHR gene in a group of oligozoospermic subjects with hypospermatogenesis and normal FSH levels.
|
20569270 |
2011 |
|
rs2075789
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The role of MSH5 C85T and MLH3 C2531T polymorphisms in the risk of male infertility with azoospermia or severe oligozoospermia.
|
19808033 |
2010 |
|
rs6166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the present study, the common G-29A, A919G, and A2039G polymorphisms in the FSHR gene were analysed in 150 (36 non-obstructive azoospermia and 114 individuals with oligozoospermia) patients and 208 normozoospermic men.
|
20170288 |
2010 |
|
rs121918346
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show that the T54A polymorphism in DAZL has no major role in Japanese males with azoospermia or oligozoospermia.
|
16123080 |
2005 |
|
rs121918346
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The phenotypes varied significantly in cases with heterozygous T54A polymorphism, ranging from hypospermatogenesis and maturation arrest to Sertoli cell-only syndrome.
|
12414900 |
2002 |
|
rs10842262
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that rs12097821 and rs10842262 were strongly associated with the risk of NOA but not total male infertility or oligozoospermia, while rs2477686 and rs6080550 were not associated with the risk of total male infertility, NOA, or oligozoospermia.
|
30863997 |
2019 |
|
rs1800734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1800734 and rs4647269 in MLH1 were found to be significantly different between severe oligozoospermia and control groups (p < 0.05).
|
31342644 |
2019 |
|
rs2477686
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that rs12097821 and rs10842262 were strongly associated with the risk of NOA but not total male infertility or oligozoospermia, while rs2477686 and rs6080550 were not associated with the risk of total male infertility, NOA, or oligozoospermia.
|
30863997 |
2019 |
|
rs2656927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the genotype frequencies of SNP rs2656927 (P = 0.014) and rs8103849 (P < 0.001) significantly differed between men with oligozoospermia in case group 1 and normozoospermic men.
|
31802345 |
2019 |
|
rs6080550
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that rs12097821 and rs10842262 were strongly associated with the risk of NOA but not total male infertility or oligozoospermia, while rs2477686 and rs6080550 were not associated with the risk of total male infertility, NOA, or oligozoospermia.
|
30863997 |
2019 |