Similarly, CC genotype and C allele frequencies of rs1219648 were detected the significant difference between the case and control groups (<i>P</i><0.01); moreover, it was still significant by the adjustion of clinical features, which indicated that rs1219648 was significantly associated with the risk of osteoporosis occurrence (OR = 2.900, 95% CI = 1.341-6.271; OR = 1.602, 95% CI = 1.126-2.279).