|
rs1555574303
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs66490707
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs66555264
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs66612022
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs67543427
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs67879854
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs72645357
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs72648326
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs72651642
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs72653170
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs72658152
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs72659319
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs768615287
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1044032
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SNP rs1044032 (P = 6.42 × 10<sup>-5</sup>, OR = 0.80) was identified as significantly associated with PMOP.
|
29855663 |
2018 |
|
rs1544410
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the bearers of C-G-C haplotype (consisting of rs7975232, rs1544410, and rs731236 unfavorable alleles), the risk of PMO was significantly higher (OR = 4.7, 95% CI 2.8-8.1, <i>p</i> < 0.0001) compared to controls.
|
29922235 |
2018 |
|
rs1044032
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on the results of an in silico prediction of the protein's functional effect based on amino acid alterations and a sequence conservation evaluation of the amino acid residues at the positions of the nsSNPs among orthologues, we selected one nsSNP in the SQRDL gene (rs1044032, SQRDL I264T) as a meaningful genetic variant associated with postmenopausal osteoporosis.
|
26258864 |
2015 |
|
rs1544410
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therapy response was independent of rs1544410 A/G SNP; instead, rs2228570 C/TSNP was associated with a better response to antiresorptive treatment, thus suggesting that the therapy for PMO should be personalized.
|
25764158 |
2015 |
|
rs1800470
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The TGF-β1 T869C and TGF-β1 T29C polymorphisms may be involved in susceptibility to PMOP, particular in Asian patients.
|
25634187 |
2015 |
|
rs1800470
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We previously reported an association between the 29C>T polymorphism in the transforming growth factor-β1 gene (rs1800470) and the prevalence of vertebral fractures in subjects with postmenopausal osteoporosis.
|
22066986 |
2012 |
|
rs73354570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs73354570 of SOX9 was significantly associated with PMOP in both discovery stages (OR 1.24 [1.10-1.39], P = 3.56 × 10<sup>-4</sup>, χ<sup>2</sup> = 12.75) and combined samples (OR 1.25 [1.15-1.37], P = 5.25 × 10<sup>-7</sup>, χ<sup>2</sup> = 25.17).
|
31732751 |
2020 |
|
rs2230911
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b><i>P2X7R</i> rs2230911 was found to be associated with serum total cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein, and BMD at the lumbar spine and hip in OP patients (<i>p</i> < 0.05).
|
31079509 |
2019 |
|
rs3751143
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>P2X7R</i> rs3751143 was shown to be associated with serum TG and hip BMD in OP patients (<i>p</i> < 0.05).
|
31079509 |
2019 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have shown that a TNFα gene polymorphism, rs1800629, is highly significantly associated with postmenopausal osteoporosis and BMD in the female Han Chinese population.
|
29481288 |
2018 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the bearers of C-G-C haplotype (consisting of rs7975232, rs1544410, and rs731236 unfavorable alleles), the risk of PMO was significantly higher (OR = 4.7, 95% CI 2.8-8.1, <i>p</i> < 0.0001) compared to controls.
|
29922235 |
2018 |
|
rs9525641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic distribution of rs9525641 in women with PO or osteopenia (OP + OPE group) differed from controls (p < 0.05), suggesting that this allele might confer a greater susceptibility to bone resorption.
|
28488893 |
2017 |