Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1906953
rs1906953
GRM4
0.820 GeneticVariation BEFREE Survival analysis for rs1906953 showed that the median survival time of osteosarcoma patients with the CC genotype was significantly shorter compared to the CT and TT genotypes; patients carrying CC genotype have apparently got a decrease in their recurrence-free survival time in comparison with patients carrying TT genotype. 26276359

2016
dbSNP: rs1906953
rs1906953
GRM4
0.820 GeneticVariation BEFREE Further analysis showed the association between rs1906953 and OS was independent of gender and age. 24984297

2014
dbSNP: rs1906953
rs1906953
GRM4
A 0.820 GeneticVariation GWASCAT Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs1906953
rs1906953
GRM4
A 0.820 GeneticVariation GWASDB Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs17206779
rs17206779
ADAMTS6
0.810 GeneticVariation BEFREE In earlier genome-wide association studies, rs7591996, rs10208273, rs17206779 and rs1906953 were identified as candidate loci for OS in Caucasians but the association of these single-nucleotide polymorphisms (SNPs) with OS in a Chinese Han population remains unknown. 24984297

2014
dbSNP: rs7591996
rs7591996 		0.810 GeneticVariation BEFREE In earlier genome-wide association studies, rs7591996, rs10208273, rs17206779 and rs1906953 were identified as candidate loci for OS in Caucasians but the association of these single-nucleotide polymorphisms (SNPs) with OS in a Chinese Han population remains unknown. 24984297

2014
dbSNP: rs17206779
rs17206779
ADAMTS6
G 0.810 GeneticVariation GWASDB Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs17206779
rs17206779
ADAMTS6
G 0.810 GeneticVariation GWASCAT Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs7591996
rs7591996 		C 0.810 GeneticVariation GWASDB Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs7591996
rs7591996 		C 0.810 GeneticVariation GWASCAT Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs2086452
rs2086452
ADAMTS17
C 0.800 GeneticVariation GWASDB Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs2086452
rs2086452
ADAMTS17
C 0.800 GeneticVariation GWASCAT Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs137853008
rs137853008
CHEK2
0.800 GeneticVariation UNIPROT

dbSNP: rs137853008
rs137853008
CHEK2
A 0.800 CausalMutation CLINVAR

dbSNP: rs7034162
rs7034162
NFIB
0.720 GeneticVariation BEFREE Single-nucleotide polymorphism rs7034162 was associated with metastasis of osteosarcoma in the Chinese population possibly via downregulation of <i>NFIB</i>. 31522615

2019
dbSNP: rs7034162
rs7034162
NFIB
A 0.720 GeneticVariation GWASCAT These data suggest that germline genetic variation at rs7034162 is important in osteosarcoma metastasis and that NFIB is an osteosarcoma metastasis susceptibility gene. 26084801

2015
dbSNP: rs7034162
rs7034162
NFIB
0.720 GeneticVariation BEFREE We identified an SNP, rs7034162, in NFIB significantly associated with metastasis in European osteosarcoma cases, as well as in cases of African and Brazilian ancestry (meta-analysis of all cases: P = 1.2 × 10(-9); OR, 2.43; 95% confidence interval, 1.83-3.24). 26084801

2015
dbSNP: rs28934576
rs28934576
TP53
0.720 GeneticVariation BEFREE Some of the genetic changes identified were in tumor suppressor genes previously identified as altered in osteosarcoma: p53 (arginine→histidine at codon 273 [R273H], R→cysteine at codon 723 [R273C], and tyrosine→C at codon 163 [Y163C]) and retinoblastoma 1 (RB1) (glutamic acid→* at codon 137 [E137*]). 22006429

2012
dbSNP: rs28934576
rs28934576
TP53
0.720 GeneticVariation BEFREE On the other hand, transfection of p53-R273H into p53 null human osteosarcoma Saos-2 cells down-regulated procaspase-3 level and induced resistance to the drug toxicity and drug-induced apoptosis. 17363498

2007
dbSNP: rs28934576
rs28934576
TP53
T 0.720 CausalMutation CLINVAR

dbSNP: rs10208273
rs10208273 		0.710 GeneticVariation BEFREE In earlier genome-wide association studies, rs7591996, rs10208273, rs17206779 and rs1906953 were identified as candidate loci for OS in Caucasians but the association of these single-nucleotide polymorphisms (SNPs) with OS in a Chinese Han population remains unknown. 24984297

2014
dbSNP: rs10208273
rs10208273 		C 0.710 GeneticVariation GWASDB Genome-wide association study identifies two susceptibility loci for osteosarcoma. 23727862

2013
dbSNP: rs28934578
rs28934578
TP53
0.710 GeneticVariation BEFREE Transfection of mutant p53 (R175H) to p53-null osteosarcoma Saos-2 cells suppressed apoptosis induced by doxorubicin (DOX), cisplatin and gamma radiation. 15578696

2005
dbSNP: rs28934578
rs28934578
TP53
T 0.710 CausalMutation CLINVAR

dbSNP: rs12146774
rs12146774
LOC105370025
T 0.700 GeneticVariation GWASCAT Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients. 29210060

2018