| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
G | 0.710 | GeneticVariation | GWASCAT | We replicated the association of rs10497394 (GWAS discovery P = 1.30 × 10(-5)) on chromosome 2 in the independent otitis media population (P = 4.7 × 10(-5); meta-analysis P = 1.52 × 10(-8)). | 23974705 | 2013 |
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|
0.710 | GeneticVariation | BEFREE | We replicated the association of rs10497394 (GWAS discovery P = 1.30 × 10(-5)) on chromosome 2 in the independent otitis media population (P = 4.7 × 10(-5); meta-analysis P = 1.52 × 10(-8)). | 23974705 | 2013 |
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|
A | 0.700 | GeneticVariation | GWASCAT | Genome-wide association analysis reveals variants on chromosome 19 that contribute to childhood risk of chronic otitis media with effusion. | 27632927 | 2016 |
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0.700 | GeneticVariation | GWASCAT | Genome-wide association analysis reveals variants on chromosome 19 that contribute to childhood risk of chronic otitis media with effusion. | 27632927 | 2016 |
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|
T | 0.700 | GeneticVariation | CLINVAR | ||||||
|
0.010 | GeneticVariation | BEFREE | The odds ratio (OR) for at least one hospitalization for any reason was increased for p.P479L homozygotes relative to noncarriers (OR=10.2, confidence interval [CI] 3.5 to 30.0) as were admissions for dental caries (OR=3.4, CI 1.5 to 7.8), acute lower respiratory tract infections (OR=6.0, CI 1.6 to 22.4), and otitis media (OR=13.5, CI 1.7 to 109.4). | 30996616 | 2019 |
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|
0.010 | GeneticVariation | BEFREE | The common FUT2 c.604C>T (p.Arg202<sup>∗</sup>) variant co-segregates with otitis media in a Filipino pedigree (LOD = 4.0). | 30401457 | 2018 |
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0.010 | GeneticVariation | BEFREE | We also identified a second hypomorphic allele, V33A, with only modest increases in auditory thresholds and reduced incidence of OM. | 28806779 | 2017 |
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|
0.010 | GeneticVariation | BEFREE | In the initial Finnish cohort, the SNP rs5030717 in the TLR4 gene region showed significant association (OR 1.33, P = .003) to OM. | 26177520 | 2015 |