|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The COMT val158met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli.
|
12595695 |
2003 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (Val158Met) of COMT leads to a three to four fold reduction in the activity of the enzyme and has been associated to modifications in the response to a pain stressor.
|
15862471 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met polymorphism affects pain perception, and subjects with the Met/Met genotype have the most pronounced response to experimental pain.
|
15927391 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This suggests that the val(1</span>58)met SNP plays a primary role in variation in temporal summation of pai</span>n, but that other SNPs of the COMT haplotype exert a greater influence on resting nociceptive sensitivity.
|
16837133 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception.
|
16674809 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception, and one study has found that migraine was less likely among those with the Val/Val polymorphism.
|
16688411 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It is shown that a polymorphism in the COMT gene, Rs4680 (Val158Met), influence pain sensitivity in human experimental pain and the efficacy for morphine in cancer pain treatment.
|
19094200 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT Val158Met and thermal pain measures were not related.
|
19464960 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetics-based personalized approaches to pain management have received a setback because of the nonreproducibility of functional genetic associations such as the pain-modulatory effect of the catechol-O-methyl transferase (COMT) gene 472G>A single-nucleotide polymorphism.
|
18548001 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism.
|
19547755 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous (val(158)met) position, designated as low (LPS), average (APS), and high pain sensitive (HPS), are associated with experimental pain sensitivity and risk of developing chronic musculoskeletal pain conditions.
|
19365560 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.
|
21049025 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT val158met polymorphism on cerebral pain processing.
|
20509977 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings provide multimeasure and multimethod support for genetic moderation of a maladaptive coping and pain process and suggest that genetic variation in the val(158)met polymorphism may affect fibromyalgia pain through pathways of pain-related cognition.
|
21130573 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we used functional Magnetic Resonance Imaging (fMRI) to investigate the brain response to heat pain stimuli in 54 subjects genotyped for the common COMT val158met polymorphism (val/val = n 22, val/met = n 20, met/met = n 12).
|
22132136 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.
|
21898113 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associated with fibromyalgia and pain sensitivity in FS Brazilian patients.
|
21120493 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our data show that the val158met polymorphism in the COMT gene contributes significantly to inter-individual differences in neural pain processing: in healthy people, this polymorphism was more related to cognitive aspects of pain processing, whereas BPD patients with reduced pain sensitivity showed an association with activity in brain regions related to affective pain processing.
|
22247753 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes.
|
23025981 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
According with previous research, our findings revealed that haplotypes of the COMT gene and genotypes of the Val158Met polymorphism play a key role on pain sensitivity in FM patients.
|
22528689 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results show that the COMT Val158Met polymorphism contributes to variability in pain sensitivity after cardiac surgery of morphine-treated patients in the intensive care unit, because Met-allele carriers were more sensitive to overall pain and procedure-related pain.
|
23210659 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no association between any of the tested pain phenotypes and SNP rs4680.
|
24343288 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggests that the Val158Met polymorphism is associated with the presence of pain in MS, but it is not a risk factor for MS itself because the presence of the Met/Met genotype was more prevalent in those patients with pain.
|
24290452 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain.
|
25218601 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain.
|
25218601 |
2014 |