Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs373611092
rs373611092
COMT ; MIR4761
0.050 GeneticVariation BEFREE The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol. 31806881

2019
dbSNP: rs373611092
rs373611092
COMT ; MIR4761
0.050 GeneticVariation BEFREE For patients with no copies of the LPS haplotype, AA of OPRM1 A118G was significantly associated with higher pain scores compared to the variant AG/GG. 27903758

2017
dbSNP: rs373611092
rs373611092
COMT ; MIR4761
0.050 GeneticVariation BEFREE Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transporter, C3435T), COMT gene (pain sensitivity, G1947A), and UGT2B7 gene (opioid metabolism, -G840A) were tested. 25576257

2015
dbSNP: rs373611092
rs373611092
COMT ; MIR4761
0.050 GeneticVariation BEFREE Further studies are needed to fully investigate the effect of MOR A118G SNP on the post operative pain scores and SC values in the larger infant population in order to validate both the clinical significance of the skin conductance for routine pain assessment in infants and the observed genetic effect. 23046994

2013
dbSNP: rs373611092
rs373611092
COMT ; MIR4761
0.050 GeneticVariation BEFREE There was a tendency towards increased pain in a gene dose-dependent manner with the mu-opioid receptor variant OPRM1 118A>G. 19514130

2009