We identified 3 common genetic variants in high linkage disequilibrium for severe pre-treatment pain, representing one genomic region at 1q44 (rs3862188, P = 3.45 × 10<sup>-8</sup>; rs880143, P = 3.45 × 10<sup>-8</sup>; and rs7526880, P = 4.92 × 10<sup>-8</sup>), which maps to the RP11-634B7.4 gene, a novel antisense gene to three olfactory receptor genes.