Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The primary aim of this study was to investigate the effects of the catechol-O-methyltransferase Val</span>158Met polymorphism on heat pain perception in a cohort of adults receiving daily opioid therapy for chronic pain. 31041874

2020

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Further the study suggested that evaluation of G472A allele of Mb.COMT gene in the patients undergoing sternotomy for monitoring pain in pre and post-surgical events. 30073475

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The Val158Met polymorphism (rs4680) does not appear to be involved in predisposition to tension-type headache; however, this genetic factor may be involved in the pathogenesis expression of CTTH, as greater pressure pain sensitivity and higher depressive levels were found in CTTH carrying the Met/Met genotype. 30614828

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The association between COMT Val158Met polymorphism (rs4680) and the inter-individual differences in the response to opioid analgesic therapy was investigated in a cohort of 87 Italian paediatric patients receiving opioids for cancer pain (STOP Pain study). 30704436

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Patients with the COMT G472A-AA genotype (rs4680) and KCNJ6 A1032G-A allele (rs2070995) CLBP responded differently to opioid titration, with higher pain intensity requiring higher dosing. 31269327

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol. 31806881

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype. 30481348

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The frequencies of COMT rs4680 "A" allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01). 28740224

2017

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE In the overall sample, rs4633 and rs4680 were significantly associated with morphine use, whereas rs4818 was associated with time-averaged pain scores. 25963335

2016

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE In Chinese patients, the incidence of postsurgical pain was significantly higher in variant COMT rs4680 genotypes (P = 0.0007) but not in the Malay or Indian cohorts. 27649267

2016

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE In conclusion, COMT rs4680 and OPRK rs6473799 polymorphisms seem to be associated with pain sensitivity. 27061127

2016

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain. 25218601

2014

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain. 25218601

2014

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heterogeneity in SCD, as suggested by the different rates of acute pain crisis. 25102390

2014

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Current results indicated that the Val158Met polymorphism seems not to be a risk factor for the development of CTS; however, it was associated with increased perception of pain and higher disability scores. 24077209

2014

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Carriers of rs6269 AA, rs4633 TT, rs4818 CC, and rs4680 AA genotypes were characterized by the lowest preoperative scores related to pain intensity and lower pain intensity at 1 year after the surgery. 24178190

2014

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE According with previous research, our findings revealed that haplotypes of the COMT gene and genotypes of the Val158Met polymorphism play a key role on pain sensitivity in FM patients. 22528689

2013

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Our results show that the COMT Val158Met polymorphism contributes to variability in pain sensitivity after cardiac surgery of morphine-treated patients in the intensive care unit, because Met-allele carriers were more sensitive to overall pain and procedure-related pain. 23210659

2013

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE There was no association between any of the tested pain phenotypes and SNP rs4680. 24343288

2013

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE This study suggests that the Val158Met polymorphism is associated with the presence of pain in MS, but it is not a risk factor for MS itself because the presence of the Met/Met genotype was more prevalent in those patients with pain. 24290452

2013

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. 21898113

2012

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associated with fibromyalgia and pain sensitivity in FS Brazilian patients. 21120493

2012

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Thus, our data show that the val158met polymorphism in the COMT gene contributes significantly to inter-individual differences in neural pain processing: in healthy people, this polymorphism was more related to cognitive aspects of pain processing, whereas BPD patients with reduced pain sensitivity showed an association with activity in brain regions related to affective pain processing. 22247753

2012

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes. 23025981

2012

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The findings provide multimeasure and multimethod support for genetic moderation of a maladaptive coping and pain process and suggest that genetic variation in the val(158)met polymorphism may affect fibromyalgia pain through pathways of pain-related cognition. 21130573

2011