rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The primary aim of this study was to investigate the effects of the catechol-O-methyltransferase Val</span>158Met polymorphism on heat pain perception in a cohort of adults receiving daily opioid therapy for chronic pain.
|
31041874 |
2020 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further the study suggested that evaluation of G472A allele of Mb.COMT gene in the patients undergoing sternotomy for monitoring pain in pre and post-surgical events.
|
30073475 |
2019 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met polymorphism (rs4680) does not appear to be involved in predisposition to tension-type headache; however, this genetic factor may be involved in the pathogenesis expression of CTTH, as greater pressure pain sensitivity and higher depressive levels were found in CTTH carrying the Met/Met genotype.
|
30614828 |
2019 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between COMT Val158Met polymorphism (rs4680) and the inter-individual differences in the response to opioid analgesic therapy was investigated in a cohort of 87 Italian paediatric patients receiving opioids for cancer pain (STOP Pain study).
|
30704436 |
2019 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with the COMT G472A-AA genotype (rs4680) and KCNJ6 A1032G-A allele (rs2070995) CLBP responded differently to opioid titration, with higher pain intensity requiring higher dosing.
|
31269327 |
2019 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol.
|
31806881 |
2019 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype.
|
30481348 |
2019 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequencies of COMT rs4680 "A" allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01).
|
28740224 |
2017 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the overall sample, rs4633 and rs4680 were significantly associated with morphine use, whereas rs4818 was associated with time-averaged pain scores.
|
25963335 |
2016 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Chinese patients, the incidence of postsurgical pain was significantly higher in variant COMT rs4680 genotypes (P = 0.0007) but not in the Malay or Indian cohorts.
|
27649267 |
2016 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, COMT rs4680 and OPRK rs6473799 polymorphisms seem to be associated with pain sensitivity.
|
27061127 |
2016 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain.
|
25218601 |
2014 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain.
|
25218601 |
2014 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heterogeneity in SCD, as suggested by the different rates of acute pain crisis.
|
25102390 |
2014 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Current results indicated that the Val158Met polymorphism seems not to be a risk factor for the development of CTS; however, it was associated with increased perception of pain and higher disability scores.
|
24077209 |
2014 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Carriers of rs6269 AA, rs4633 TT, rs4818 CC, and rs4680 AA genotypes were characterized by the lowest preoperative scores related to pain intensity and lower pain intensity at 1 year after the surgery.
|
24178190 |
2014 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
According with previous research, our findings revealed that haplotypes of the COMT gene and genotypes of the Val158Met polymorphism play a key role on pain sensitivity in FM patients.
|
22528689 |
2013 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results show that the COMT Val158Met polymorphism contributes to variability in pain sensitivity after cardiac surgery of morphine-treated patients in the intensive care unit, because Met-allele carriers were more sensitive to overall pain and procedure-related pain.
|
23210659 |
2013 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no association between any of the tested pain phenotypes and SNP rs4680.
|
24343288 |
2013 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggests that the Val158Met polymorphism is associated with the presence of pain in MS, but it is not a risk factor for MS itself because the presence of the Met/Met genotype was more prevalent in those patients with pain.
|
24290452 |
2013 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.
|
21898113 |
2012 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associated with fibromyalgia and pain sensitivity in FS Brazilian patients.
|
21120493 |
2012 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our data show that the val158met polymorphism in the COMT gene contributes significantly to inter-individual differences in neural pain processing: in healthy people, this polymorphism was more related to cognitive aspects of pain processing, whereas BPD patients with reduced pain sensitivity showed an association with activity in brain regions related to affective pain processing.
|
22247753 |
2012 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes.
|
23025981 |
2012 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings provide multimeasure and multimethod support for genetic moderation of a maladaptive coping and pain process and suggest that genetic variation in the val(158)met polymorphism may affect fibromyalgia pain through pathways of pain-related cognition.
|
21130573 |
2011 |