Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13361160
rs13361160
C 0.800 GeneticVariation GWASCAT Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. 22956598

2013

dbSNP: rs13361160
rs13361160
C 0.800 GeneticVariation GWASDB Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. 22956598

2013

dbSNP: rs17122021
rs17122021
0.800 GeneticVariation GWASDB Genome-wide association study of acute post-surgical pain in humans. 19207018

2009

dbSNP: rs17122021
rs17122021
0.800 GeneticVariation GWASCAT Genome-wide association study of acute post-surgical pain in humans. 19207018

2009

dbSNP: rs2562456
rs2562456
0.800 GeneticVariation GWASDB Genome-wide association study of acute post-surgical pain in humans. 19207018

2009

dbSNP: rs2562456
rs2562456
0.800 GeneticVariation GWASCAT Genome-wide association study of acute post-surgical pain in humans. 19207018

2009

dbSNP: rs1972597
rs1972597
G 0.700 GeneticVariation GWASCAT Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients. 27670397

2016

dbSNP: rs3862188
rs3862188
G 0.700 GeneticVariation GWASCAT We identified 3 common genetic variants in high linkage disequilibrium for severe pre-treatment pain, representing one genomic region at 1q44 (rs3862188, P = 3.45 × 10<sup>-8</sup>; rs880143, P = 3.45 × 10<sup>-8</sup>; and rs7526880, P = 4.92 × 10<sup>-8</sup>), which maps to the RP11-634B7.4 gene, a novel antisense gene to three olfactory receptor genes. 27670397

2016

dbSNP: rs1057518927
rs1057518927
OAT
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1057518946
rs1057518946
T 0.700 GeneticVariation CLINVAR

dbSNP: rs121908552
rs121908552
A 0.700 GeneticVariation CLINVAR

dbSNP: rs1445287184
rs1445287184
T 0.700 CausalMutation CLINVAR

dbSNP: rs1554781700
rs1554781700
T 0.700 GeneticVariation CLINVAR

dbSNP: rs1555735545
rs1555735545
A 0.700 CausalMutation CLINVAR

dbSNP: rs28937900
rs28937900
A 0.700 CausalMutation CLINVAR

dbSNP: rs397514698
rs397514698
T 0.700 CausalMutation CLINVAR

dbSNP: rs781565158
rs781565158
G 0.700 CausalMutation CLINVAR

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The primary aim of this study was to investigate the effects of the catechol-O-methyltransferase Val</span>158Met polymorphism on heat pain perception in a cohort of adults receiving daily opioid therapy for chronic pain. 31041874

2020

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE The single-nucleotide polymorphism, A118G of the mu opioid receptor gene (oprm1), has been associated with altered pain perception. 30873885

2019

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE Accordingly, a functional μ-opioid receptor (OPRM1) polymorphism (C77G in primates, A118G in humans) affecting opioidergic signaling has been associated with separation distress and attachment behavior in nonhuman primates, and social pain sensitivity in humans. 31772303

2019

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE The Relevance of the OPRM1 118A>G Genetic Variant for Opioid Requirement in Pain Treatment: A Meta-Analysis. 31337162

2019

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE Few associations replicated: morphine dose (mcg/kg) in African American children and ABCB1 rs1045642 (A allele, β = -9.30, 95% CI: -17.25 to -1.35, p = 0.02) and OPRM1 rs1799971 (G allele, β = 23.19, 95% CI: 3.27-43.11, p = 0.02); KCNJ6 rs2211843 and high pain in African American subjects (T allele, OR 2.08, 95% CI: 1.17-3.71, p = 0.01) and in congruent European Caucasian pain phenotypes; and COMT rs740603 for high pain in European Caucasian subjects (A allele, OR: 0.69, 95% CI: 0.48-0.99, p = 0.046). 30760877

2019

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol. 31806881

2019

dbSNP: rs1799971
rs1799971
0.100 GeneticVariation BEFREE In subgroup analysis, we did not find statistically significant correlation between OPRM1 A118G polymorphism and opioid pain relief among Caucasian patients (SMD=-0.15; 95% CI, -0.29 to -0.00; P=0.04), as well as among morphine users (SMD =-0.20; 95% CI, -0.40 to 0.00, P=0.05), except for Asian patients (SMD=-0.42; 95% CI, -0.62 to -0.23; P<0.001). 30028366

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Further the study suggested that evaluation of G472A allele of Mb.COMT gene in the patients undergoing sternotomy for monitoring pain in pre and post-surgical events. 30073475

2019