rs13361160
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.
|
22956598 |
2013 |
rs13361160
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.
|
22956598 |
2013 |
rs17122021
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
rs17122021
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
rs2562456
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
rs2562456
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
rs1972597
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients.
|
27670397 |
2016 |
rs3862188
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
We identified 3 common genetic variants in high linkage disequilibrium for severe pre-treatment pain, representing one genomic region at 1q44 (rs3862188, P = 3.45 × 10<sup>-8</sup>; rs880143, P = 3.45 × 10<sup>-8</sup>; and rs7526880, P = 4.92 × 10<sup>-8</sup>), which maps to the RP11-634B7.4 gene, a novel antisense gene to three olfactory receptor genes.
|
27670397 |
2016 |
rs1057518927
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1057518946
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs121908552
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1445287184
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1554781700
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1555735545
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs28937900
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs397514698
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs781565158
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The primary aim of this study was to investigate the effects of the catechol-O-methyltransferase Val</span>158Met polymorphism on heat pain perception in a cohort of adults receiving daily opioid therapy for chronic pain.
|
31041874 |
2020 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphism, A118G of the mu opioid receptor gene (oprm1), has been associated with altered pain perception.
|
30873885 |
2019 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Accordingly, a functional μ-opioid receptor (OPRM1) polymorphism (C77G in primates, A118G in humans) affecting opioidergic signaling has been associated with separation distress and attachment behavior in nonhuman primates, and social pain sensitivity in humans.
|
31772303 |
2019 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Relevance of the OPRM1 118A>G Genetic Variant for Opioid Requirement in Pain Treatment: A Meta-Analysis.
|
31337162 |
2019 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Few associations replicated: morphine dose (mcg/kg) in African American children and ABCB1 rs1045642 (A allele, β = -9.30, 95% CI: -17.25 to -1.35, p = 0.02) and OPRM1 rs1799971 (G allele, β = 23.19, 95% CI: 3.27-43.11, p = 0.02); KCNJ6 rs2211843 and high pain in African American subjects (T allele, OR 2.08, 95% CI: 1.17-3.71, p = 0.01) and in congruent European Caucasian pain phenotypes; and COMT rs740603 for high pain in European Caucasian subjects (A allele, OR: 0.69, 95% CI: 0.48-0.99, p = 0.046).
|
30760877 |
2019 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol.
|
31806881 |
2019 |
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In subgroup analysis, we did not find statistically significant correlation between OPRM1 A118G polymorphism and opioid pain relief among Caucasian patients (SMD=-0.15; 95% CI, -0.29 to -0.00; P=0.04), as well as among morphine users (SMD =-0.20; 95% CI, -0.40 to 0.00, P=0.05), except for Asian patients (SMD=-0.42; 95% CI, -0.62 to -0.23; P<0.001).
|
30028366 |
2019 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further the study suggested that evaluation of G472A allele of Mb.COMT gene in the patients undergoing sternotomy for monitoring pain in pre and post-surgical events.
|
30073475 |
2019 |