rs1444669684
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors.
|
26408346 |
2016 |
rs1444669684
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas.
|
17349581 |
2007 |
rs1444669684
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival.
|
23980075 |
2013 |
rs121913529
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Pancreas-specific disruption of Pik3ca or Rac1, but not Pik3cb, prevented the development of pancreatic tumors in Kras(G12D/+);Ptf1a(Cre/+) mice.
|
25311989 |
2014 |
rs121913529
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors.
|
26408346 |
2016 |
rs121913444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pyrosequencing of the primary pancreatic tumor antecedent to metastasis showed an uncommon EGFR mutation at L861Q in the kinase domain of exon 21.
|
29695402 |
2018 |
rs1399364791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice.
|
25050737 |
2014 |
rs169068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No somatic mutations were identified, but 3 nonsynonymous SSTR5 SNPs (P109S, L48M, and P335L) in pancreatic tumors were identified.
|
21692047 |
2011 |
rs1799939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G691S RET polymorphism was also detected in human pancreatic tumors and represented a somatic mutation in some patients.
|
16357163 |
2005 |
rs200081710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Listeria also penetrated the transgenic KPC (conditionally express endogenous Kras-G12D and p53-R172H mutant alleles) pancreatic tumors and metastases.
|
28186976 |
2017 |
rs2066827
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CDKN1B also harbors single nucleotide polymorphisms; the T/G transversion at nucleotide 326 (the V109G variant) has been reported to be protective in breast, hereditary prostate, and pancreatic tumors.
|
21177330 |
2011 |
rs4988483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No somatic mutations were identified, but 3 nonsynonymous SSTR5 SNPs (P109S, L48M, and P335L) in pancreatic tumors were identified.
|
21692047 |
2011 |
rs61734659
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The heterozygous p.G191R variant was found in three of 241 (1.2%) patients with chronic pancreatitis, in seven of 174 (4.0%) patients with acute pancreatitis, and in 12 of 189 (6.3%) patients with pancreatic neoplasm.
|
19052022 |
2009 |
rs748405415
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The heterozygous p.G191R variant was found in three of 241 (1.2%) patients with chronic pancreatitis, in seven of 174 (4.0%) patients with acute pancreatitis, and in 12 of 189 (6.3%) patients with pancreatic neoplasm.
|
19052022 |
2009 |
rs752021744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pancreas-specific disruption of Pik3ca or Rac1, but not Pik3cb, prevented the development of pancreatic tumors in Kras(G12D/+);Ptf1a(Cre/+) mice.
|
25311989 |
2014 |
rs762846821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas.
|
17349581 |
2007 |
rs764664272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice.
|
25050737 |
2014 |
rs1057520011
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).
|
20581473 |
2010 |
rs1057520013
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).
|
20581473 |
2010 |
rs756231248
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).
|
20581473 |
2010 |
rs786202134
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.
|
21189378 |
2011 |
rs786202134
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.
|
21189378 |
2011 |
rs1064794292
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs121913385
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|