|
rs1001179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, clinical-pharmacogenetic model for prediction of time to occurrence of dyskinesia included female sex (HR = 1.07), age at diagnosis (HR = 0.97), tremor-predominant Parkinson's disease (HR = 0.88), beta-blockers (HR = 0.95), alcohol consumption (HR = 0.99), time from diagnosis to initiation of levodopa treatment (HR = 1.15), <i>CAT</i> rs1001179 (HR = 1.27), <i>SOD2</i> rs4880 (HR = 0.95), <i>NOS1</i> rs2293054 (HR = 0.99), <i>COMT</i> rs165815 (HR = 0.92), and <i>SLC22A1</i> rs628031 (HR = 0.80).
|
31156712 |
2019 |
|
rs10014396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A number of SNCA variants, not including rs10014396 or rs3775439, were significantly associated with susceptibility to PD.
|
22912757 |
2012 |
|
rs10079250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No statistically significant differences in allelic and genotypic frequencies of <i>CSF1R</i> rs10079250 between the PD and control subjects were found, even after stratification by age at onset and gender.
|
31554150 |
2019 |
|
rs1013639215
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No common PITX3 variants were associated with PD, although a rare missense change (G32S) was found in only one patient and none of the controls.
|
20468068 |
2010 |
|
rs1014290
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, SLC2A9 rs1014290</span> is related to lower uric acid levels in PD patients and can be a risk factor for PD in the Han population.
|
29158942 |
2017 |
|
rs10214163
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While no other SNP achieved study-wide significance, one SNP (rs10214163) influencing Parkinson's disease displayed nominally significant association with olanzapine and quetiapine response, while the second such SNP (rs30196) showed a statistical trend toward correlating with olanzapine and quetiapine response.
|
23886675 |
2013 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b>We found that the frequency of the CCL2 genotype of rs1024611</span> was significantly different between the PD and control groups (<i>p</i> = 0.021), while the C allele was associated with a significantly increased risk in the PD group (<i>p</i> = 0.004).
|
30761072 |
2019 |
|
rs10247962
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we observed a suggestive protective association (OR=0.87, 95% CI: 0.74-1.02) between PD and a haplotype composed of the G allele at rs10247962 and the A allele at rs4434553 in transferrin receptor 2 (TFR2; GeneID: 7036).
|
24121126 |
2014 |
|
rs10256359
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
rs10380
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we stratified our patients based on the MTHFR 677TT genotype in different strata, a significant association between the joint effect of polymorphisms and PD risk was observed in those patients whose genotypes were MTRR A1049G/MTR A2756G or MTRR C1783T/MTR A2756G (P<0.05).
|
21070756 |
2011 |
|
rs10410544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs related to SIRT1, rs3740051, rs7895833, rs7069102, rs2273773, and rs4746720 and two SNPs related to SIRT2, rs10410544, and rs45592833 did not show an association with PD risk in this study.
|
31214610 |
2019 |
|
rs1043424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested the hypothesis that three common coding variations (Leu63Leu, Ala340Thr and Asn521Thr) could increase the risk of PD.
|
15542245 |
2004 |
|
rs1044396
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggested that the CHRNA4 rs1044396 CT/TT genotype is related to cigarette smoking, that the rs1044397 polymorphism may associate with PD age of onset in women, and that rs1044396 and rs1044397 may relate to pain in PD patients, but not to the course or severity of disease, or to depression or nocturnal or sleeping disorders.
|
26125703 |
2015 |
|
rs1044396
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, we found no significant link to CHRNA4:rs1044396 genotypes to baseline attention variables in PD or in controls.
|
20493238 |
2010 |
|
rs1044397
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, in women, PD onset was latest in rs1044397 GA/AA (P = 0.015). rs1044396 CT/TT genotype carriers and rs104</span>4397 GG genotype patients with PD had higher VAS scores.
|
26125703 |
2015 |
|
rs10445337
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
|
rs10445338
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
|
rs10445364
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our results suggest that the C3435T polymorphism may not play an important role in PD susceptibility in Japanese.
|
22971641 |
2013 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The frequency of each individual SNPs; -41 A > G (intron -1), -145 C > G (exon 1), -129 T > C (exon 1), 1236 T > C (exon 12), 2677 G > T/A (exon 21), 3435 C > T (exon 26), and 4036 A > G (exon 28) did not differ between PD and controls.
|
15542248 |
2004 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Among 207 cases and 482 matched controls, ABCB1 polymorphisms were not associated with PD (C3435T, P = .43; G2677[A,T], P = .97).
|
20558393 |
2010 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In a population-based case control study, we genotyped ABCB1 gene variants at rs1045642 (c.3435C/T) and rs2032582 (c.2677G/T/A) and assessed occupational exposures to organochlorine (OC) and organophosphorus (OP) pesticides based on self-reported occupational use and record-based ambient workplace exposures for 282 PD cases and 514 controls of European ancestry.
|
26457621 |
2015 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
However, the association between the MDR1 polymorphisms (C1236T and C3435T) and its susceptibility to PD is inconclusive.
|
27538645 |
2016 |
|
rs1045642
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The NOS1 exon18 and ABCB1 1236C/T variants might play a role in the risk of Parkinson's disease, whereas NOS1 exon29 and ABCB1 3435C/T polymorphisms might not contribute to PD susceptibility.
|
27749554 |
2016 |
|
rs10463554
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.
|
28892059 |
2017 |