Gene: SNCA ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
0.900 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
0.900 GeneticVariation BEFREE SNP rs356219 of the α-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population. 22349157

2012
dbSNP: rs11931074
rs11931074
SNCA ; LOC105377329
0.900 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
0.900 GeneticVariation BEFREE Single-nucleotide polymorphisms in MAPT (rs1800547; P = 3.1 × 10(-4) ) and SNCA (rs356219; P = 5.5 × 10(-4) ) were significantly associated with Parkinson's disease. 21425343

2011
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
G 0.900 GeneticVariation GWASDB Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. 21292315

2011
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
0.900 GeneticVariation BEFREE Our findings indicate that as previously reported, the SNCA rs356219-G allele and MAPT rs1052553 (H1 haplotype) were both associated with an increased risk of PD, whilst contrary to previous reports, GSK3B variants were not. 21159074

2011
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
G 0.900 GeneticVariation GWASCAT Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. 21292315

2011
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
0.900 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
dbSNP: rs11931074
rs11931074
SNCA ; LOC105377329
0.900 GeneticVariation GWASDB Genome-wide association study reveals genetic risk underlying Parkinson's disease. 19915575

2009
dbSNP: rs11931074
rs11931074
SNCA ; LOC105377329
0.900 GeneticVariation GWASCAT Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. 19915576

2009
dbSNP: rs11931074
rs11931074
SNCA ; LOC105377329
G 0.900 GeneticVariation GWASDB Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. 19915576

2009
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
0.900 GeneticVariation BEFREE Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263-bp allele, rs356165 and rs356219). 18485051

2008
dbSNP: rs356219
rs356219
SNCA ; LOC105377329
0.900 GeneticVariation BEFREE We also performed an association study of the noncoding polymorphisms rs2737029 (A/G) and rs356204 (A/G) (intron 4), and of rs356219 (T/C) (3'-region) of SNCA in a Swedish PD case-control material. 18606870

2008
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation BEFREE After narrowing down the variants using the <i>p</i> < 1 × 10<sup>-5</sup> cutoff, in overall populations, seven SNPs increased the risk of PD (rs2736990, rs356220, rs356165, rs181489, rs356219, rs11931074, and rs2737029, with odds ratios [ORs] of 1.22-1.38) and one SNP decreased the risk (rs356186, with an OR of 0.77). 30410434

2018
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation BEFREE Our meta-analysis provides evidence that the T allele, TT and TC genotype of rs2736990(C/T) polymorphism may decrease the risk of PD. 28844730

2017
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation GWASDB Identification of a novel Parkinson's disease locus via stratified genome-wide association study. 24511991

2014
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation BEFREE Our study demonstrated that SNCA rs2736990 C > T polymorphism was associated with susceptibility to PD in Chinese Han population. 24005725

2014
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation BEFREE Our results show that rs2736990 and rs356220 in SNCA decreased the risk for PD in a Chinese population. 25129240

2014
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815

2012
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation BEFREE In the additive model, SNP rs2736990 was significantly related to the risk of sporadic PD: the adjusted OR was 1.30 (95% CI: 1.002-1.68). 22425546

2012
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487

2011
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation BEFREE Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P = 1.63 × 10(-5), OR = 1.325 and BST1, rs12502586: P = 1.63 × 10(-3), OR = 1.337). 21248740

2011
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation GWASCAT Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. 20070850

2010
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation GWASDB Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. 20711177

2010
dbSNP: rs2736990
rs2736990
SNCA
0.860 GeneticVariation GWASDB Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. 20070850

2010