|
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs356219 of the α-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population.
|
22349157 |
2012 |
|
rs356219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphism rs356219 in the α-synuclein (SNCA) gene has been shown to significantly contribute to an earlier age at onset of Parkinson's disease (PD), and regulates SNCA expression in PD brain regions, blood, and plasma.
|
29505953 |
2018 |
|
rs2736990
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In the additive model, SNP rs2736990 was significantly related to the risk of sporadic PD: the adjusted OR was 1.30 (95% CI: 1.002-1.68).
|
22425546 |
2012 |
|
rs2736990
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Our study demonstrated that SNCA rs2736990 C > T polymorphism was associated with susceptibility to PD in Chinese Han population.
|
24005725 |
2014 |
|
rs2736990
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Our results show that rs2736990 and rs356220 in SNCA decreased the risk for PD in a Chinese population.
|
25129240 |
2014 |
|
rs2736990
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Our meta-analysis provides evidence that the T allele, TT and TC genotype of rs2736990(C/T) polymorphism may decrease the risk of PD.
|
28844730 |
2017 |
|
rs2736990
|
|
|
0.860 |
GeneticVariation |
BEFREE |
After narrowing down the variants using the <i>p</i> < 1 × 10<sup>-5</sup> cutoff, in overall populations, seven SNPs increased the risk of PD (rs2736990, rs356220, rs356165, rs181489, rs356219, rs11931074, and rs2737029, with odds ratios [ORs] of 1.22-1.38) and one SNP decreased the risk (rs356186, with an OR of 0.77).
|
30410434 |
2018 |
|
rs2736990
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P = 1.63 × 10(-5), OR = 1.325 and BST1, rs12502586: P = 1.63 × 10(-3), OR = 1.337).
|
21248740 |
2011 |
|
rs356220
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The additive interactions between SNPs rs356219 and rs356220 and smoking with respect to sporadic PD were significant although the multiplicative interactions were not significant.
|
22425546 |
2012 |
|
rs356220
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Our results show that rs2736990 and rs356220 in SNCA decreased the risk for PD in a Chinese population.
|
25129240 |
2014 |
|
rs356220
|
|
|
0.850 |
GeneticVariation |
BEFREE |
SNCA_ rs356220 was associated with both Sporadic-PD (OR = 1.37, P = 1 × 10(-9)) and Familial-PD (OR = 1.40, P = 2 × 10(-5)).
|
24511991 |
2014 |
|
rs356220
|
|
|
0.850 |
GeneticVariation |
BEFREE |
We provided further evidence that rs356220 is associated with increased risk of PD supporting previous studies in Caucasian-based and Japanese populations.
|
26732583 |
2016 |
|
rs356220
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Compared with subjects with the CC or CA genotype of UCHL1 S18Y and the CC or CT genotype of SNCA SNP rs356220, those with the AA genotype of UCHL1 S18Y and the TT genotype of SNP rs356220 had a significantly increased risk of sporadic PD; the interaction, however, was not significant.
|
22839974 |
2012 |
|
rs356165
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263-bp allele, rs356165 and rs356219).
|
18485051 |
2008 |
|
rs356165
|
|
|
0.780 |
GeneticVariation |
BEFREE |
No statistically significant difference in genotype frequency between cases and controls was observed (P=0.863), suggesting no association of SNP rs356165 with PD in our population.
|
20478361 |
2010 |
|
rs356165
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms.
|
24418406 |
2014 |
|
rs356165
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Our work highlights rs356165 as an important determinant of the risk of developing PD and early age at onset and encourages future research to identify a functional effect on SNCA expression.
|
22076805 |
2012 |
|
rs356165
|
|
|
0.780 |
GeneticVariation |
BEFREE |
The three single nucleotide polymorphisms (SNPs) of the promoter region (rs2583988, rs2619364, rs2619363) and a SNP in the 3'UTR (rs356165) of the SNCA gene showed the greatest evidence for an association with PD (p <or= 0.003), with significant pairwise values for linkage disequilibrium (D' >or= 0.74, r (2) >or= 0.29).
|
17872362 |
2007 |
|
rs356165
|
|
|
0.780 |
GeneticVariation |
BEFREE |
The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007).
|
19890971 |
2009 |
|
rs356165
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Our study finds some evidence that head injury and D4S3481 or rs356165 variants jointly increase the risk of PD but little evidence of interaction.
|
25370538 |
2015 |
|
rs356165
|
|
|
0.780 |
GeneticVariation |
BEFREE |
In summary, we confirmed that Rep1, rs356165, and rs11931074 in SNCA gene, G2385R in LRRK2 gene, rs4698412 in BST1 gene, rs1564282 in PARK17, and L444P in GBA gene have an independent and combined significant association with PD.
|
25623333 |
2015 |
|
rs356182
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Our study firstly demonstrates that SNCA rs356182 variant has an increased risk of susceptibility to PD in Han Chinese population.
|
27538639 |
2016 |
|
rs356182
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype.
|
28078311 |
2017 |
|
rs356182
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Here, in order to discover potential AD-related loci, we investigated the association between late-onset AD (LOAD) susceptibility and nine single-nucleotide polymorphisms (SNPs) (rs11724635 of BST1, rs12637471 of MCCC1, rs15553999 of TMEM229, rs17649553 of MAPT, rs34311866 of TMEM175-GAK-DGKQ, rs356182 of SNCA, rs6430538 of ACMSD-TMEM163, rs76904798 of LRRK2 and rs823118 of RAB7L1-NUCKS1) which were reported to have genome-wide significant associations with PD risk in a recent Genome Wide Association Study performed among white population.
|
26738859 |
2017 |
|
rs356182
|
|
|
0.740 |
GeneticVariation |
BEFREE |
In MR between α-synuclein in PD with AD risk, we only extracted rs356182 as the IV through a strict screening process.
|
30598082 |
2018 |