|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNCA rs11931074 polymorphism is found to be associated with PD risk and this risk appears to be influenced by genetic status and ethnicity.
|
31758346 |
2020 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In an interaction analysis, SNP rs11931074-PD status interaction was significantly associated with positive α-Syn immunostaining in the ENS (OR = 7.33, 95% CI = 1.58-33.88, P = 0.01).
|
30424941 |
2019 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Also blood sample of each participant was genotyped for rs11931074 polymorphism (PD: TT = 19, GT = 32, GG = 11; HC: TT = 10, GT = 25, GG = 12) and then examined to ascertain the influence of different genotypes on regional brain activity with amplitude low-frequency fluctuation analysis (ALFF).
|
31243602 |
2019 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis further indicates that the SNCA rs11931074 polymorphism contributes to PD susceptibility.
|
30120622 |
2018 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association of rs11931074 with decreased risk of PD was also significant.
|
26732583 |
2016 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Subgroup analysis of patients with both clinical and genetic results demonstrated that after adjusting for age, sex, chronic constipation and cpRBD, rs11931074 TT genotype may increase the risk of hyposmia in PD (OR = 3.24 95% CI = 1.23-8.51, p = 0.017) compared to GG genotype via an additive model.
|
25921825 |
2015 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results suggest that the rs3822086 (C) allele and rs11931074 (G) allele in SNCA decrease the risk for PD, and SNCA rs11931074 may affect frontal lobe dysfunction of MSA in the Chinese population.
|
26208350 |
2015 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found that Rep1, rs356165, and rs11931074 in SNCA gene; G2385R in LRRK2 gene; rs4698412 in BST1 gene; rs1564282 in PARK17; and L444P in GBA gene were associated with PD with adjustment of sex and age (p < 0.05) in the analysis of 16 variants.
|
25623333 |
2015 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms.
|
24418406 |
2014 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNP rs894278 confers risk via a dominant model and an additive model, whereas the minor allele G of rs11931074 reduces the risk of PD progression.
|
23853107 |
2013 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study showed that two SNPs near the promoter region (rs2301134 and rs2301135) of SNCA gene gave the greatest evidence for an association with PD (p ≤ 0.01) and a haplotype block with two SNPs in the 3' UTR (rs356221 and rs11931074) revealed another evidence of association (p ≤ 0.02).
|
23182315 |
2013 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Of those, the SNCA SNP rs11931074 showed the most significant association with PD susceptibility (adjusted odds ratio = 1.48; 95% confidence interval = 1.31-1.67; p = 2.20E-10).
|
23820587 |
2013 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
|
21738487 |
2011 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
|
19915575 |
2009 |
|
rs11931074
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
|
19915576 |
2009 |
|
rs11931074
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
|
19915576 |
2009 |