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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
Studies on various global populations have determined that mutations such as G2019S, G2385R, and R1628P in LRRK2 increase the risk of developing PD while the N551K-R1398H haplotype is associated with conferring protection against developing PD.
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31487119 |
2019 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
G2019S variant is rare in Asian populations, whereas two other Asian-specific LRRK2 variants, G2385R and R1628P, are more frequent with a twofold increased risk of PD.
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31041581 |
2019 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
Leucine-rich repeat kinase 2 (LRRK2) has been recently identified as a causative gene of Parkinson's disease (PD), and the LRRK2 R1628P and G2385R mutations are common in ethnic Han-Chinese PD patients.
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29567424 |
2018 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
Reprogramming of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient with a R1628P variant in the LRRK2 gene.
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28395802 |
2017 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
But the molecular pathological mechanisms of R1628P mutation in PD is still unknown.
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26930193 |
2016 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
The analysis assessing the role of R1628P on the risk of PD in ethnic Han-Chinese supported a significant association, and the odds ratio was 1.86.
|
27812003 |
2016 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
The present data indicate that the R1628P polymorphism of the LRRK2 gene contributes to PD susceptibility in Asian, especially Chinese, populations.
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27384489 |
2016 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
The results indicated that LRRK2 R1628P variants were increased risk of PD when all studies were pooled (C vs. G OR=1.983, 95% CI 1</span>.640-2.399; GC+CC vs. GG OR=1.971, 95% CI 1.625-2.391).
|
27133195 |
2016 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
Compared to caffeine takers with the wild-type genotype (low genetic susceptibility), non-caffeine takers with R1628P variant (high genetic susceptibility) had a 15 times increased risk of developing PD (OR = 15.4, 95% CI = (1.94, 122), P = 0.01), whereas caffeine takers with R1628P (intermediate susceptibility) had a 3 times risk (OR = 3.07, 95% CI = (2.02, 4.66), P < 0.001).
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26522888 |
2015 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
The objectives of this study were to identify PD subtypes using cluster analysis (CA) and to determine the association between the subtypes and the polymorphisms in LRRK2 (G2385R and R1628P) and GBA (L444P) genes.
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25732803 |
2015 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
Using a case control methodology, we demonstrated an association between a known PD risk variant, LRRK2 R1628P, with ET.
|
25761573 |
2015 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
The G2385R and R1628P variants were associated with a 2.2-fold (P = 0.019) and 1.2-fold (P = 0.054) increased risk of PD, respectively.
|
25243190 |
2014 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
In this study, we have investigated motor and non-motor aspects in 1638 Chinese PD patients who carried LRRK2 G2385R or R1628P (LRRK2-PD, n = 223), GBA L444P variant (GBA-PD, n = 49), or none of the variants (idiopathic PD [IPD], n = 1366).
|
24095219 |
2014 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
We confirm the association between p.R1628P and risk of developing PD in the appropriated sample-sized cohort.
|
24997548 |
2014 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
For the LRRK2 gene, only R1628P variants of total 16 SNPs giving a marginal significant association with PD across the whole gene (p = 0.0058) and no haplotype block was constructed.
|
23182315 |
2013 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
This study aimed to investigate whether G2385R and R1628P variants are associated with sporadic PD in this population.
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23624603 |
2013 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
To investigate potential genetic risk factors for PD in a northern Han Chinese population, six single nucleotide polymorphisms (SNP) (R366W, V380L, P196S, R1628P, G2385R and R461W) located in four PARK genes were multiplex-amplified in two independent polymerase chain reaction (PCR) systems.
|
22575062 |
2012 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
There were genetic associations between four variants (G2019S, G2385R, R1628P and A419V) and increased PD risk, while there was no evidence of statistically significant association between P755L and PD.
|
22575234 |
2012 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
The only validated coding susceptibility alleles for PD, G2385R and R1628P, are both in this gene but to date have been found exclusively in Asian populations.
|
21641266 |
2011 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
We analyzed a LRRK2 PD (R1628P) risk variant in a group of 885 subjects comprising of AD and controls.
|
20018409 |
2011 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
In addition, we also explored the potential relationship between GBA L444P mutation and LRRK2 G2385R and R1628P variants in patients with PD.But no association was found, either.
|
20004703 |
2010 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
We and others found two polymorphic LRRK2 (leucine-rich repeat kinase 2) variants (rs34778348:G>A; p.G2385R and rs33949390:G>C; p.R1628P) associated with Parkinson disease (PD) among Chinese patients, but the common worldwide rs34637584:G>A; p.G2019S mutation, was absent.
|
20186690 |
2010 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
The G2385R (SNP accession no. rs34778348) and R1628P (rs33949390) variants of leucine-rich repeat kinase 2 (LRRK2, PARK8) are emerging as an important risk factor for Parkinson's disease (PD) in the ethnic Chinese and Japanese populations.
|
19854095 |
2010 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
Two polymorphic variants found almost exclusively among Asians (G2385R and R1628P) have been shown to increase the Parkinson's disease risk by approximately two-fold.
|
19804413 |
2009 |
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rs33949390
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0.100 |
GeneticVariation |
BEFREE |
In the PD group, 17 patients (5.2%) were heterozygous for the R1628P variant.
|
19699188 |
2009 |