|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The meta-analysis included eight association studies for the PITX3 rs3758549 SNP (4,052 PD patients, 3,949 controls), eight studies for the PITX3 rs2281983 SNP (4,309 PD patients, 4,287 controls), and six studies for the rs4919621 SNP (2,724 PD patients, 2,285 controls), and the risk for PD, global diagnostic odds ratios (95% confidence intervals) for rs3758549, rs2281983, and rs4919621 were, respectively, 1.00 (0.89-1.12) (p = 0.979), 0.99 (0.91-1.09) (p = 0.896), and 0.98 (0.83-1.16) (p = 0.844) for the total group.
|
24525476 |
2014 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of meta-analysis suggested that the PITX3 SNP r</span>s3758549 was significantly associated with risk of PD in the Asian population (genotype TT+TC vs. CC, P=0.014; allele T vs. C, P=0.019) but not in the Caucasian population (genotype TT+TC vs. CC, P=0.053; allele T vs. C, P=0.251).
|
24394914 |
2014 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous finding suggesting three SNPs (rs2281983, rs4919621 and rs3758549) in the PITX3 gene to be associated with PD could not be replicated.
|
22411443 |
2012 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several studies have indicated that three PITX3 single nucleotide polymorphisms (SNPs), rs2281983, rs4919621 and rs3758549, are likely to be associated with Parkinson's disease (PD) in Caucasians.
|
22037506 |
2011 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of meta-analysis further support that th</span>e PITX3 gene rs3758549</span> polymorphism is associated with PD: Z=3.09, p=0.002, OR=0.89.
|
21524731 |
2011 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent association studies indicated that three PITX3 single nucleotide polymorphisms (SNPs), including rs2281983, rs4919621, and rs3758549 are likely to be associated with PD.
|
21565251 |
2011 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, our highly significant findings regarding the association of rs3758549</span> reproduce the results of the initial report on transcription factor gene variants, providing further evidence for PITX3 and EN1 polymorphisms as potential genetic risk factors for sporadic PD.
|
19345444 |
2011 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease.
|
21469209 |
2011 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the SNP rs3758549 (C >T substitution) in the Pitx3 gene is a potential risk for sporadic PD, especially early-onset PD in Chinese Han population.
|
21138504 |
2011 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, a previous finding suggesting a SNP (rs3758549) in the putative promoter region of the PITX3 gene to be associated with PD could not be replicated.
|
18420308 |
2010 |
|
rs3758549
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We provide evidence for a novel, strong and reproducible association of the PITX3 promoter SNP rs3758549: C>T (p=0.004) with PD.
|
17905480 |
2009 |