Three SNPs of TLR4, i.e., rs1927911 (TT/CC+CT), rs2149356 (TT/GG+GT) and rs2737190 (GG/AA+AG), were associated with moderate/severe chronic periodontitis in Chinese population infected with <i>P. gingivalis</i>.<i>P. gingivalis</i>, which interacted with TLR4 gene plays an important role in the pathogenesis of periodontitis.