|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Use of aromatase inhibitors in large cell calcifying sertoli cell tumors: effects on gynecomastia, growth velocity, and bone age.
|
25226294 |
2014 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance.
|
23240097 |
2013 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
High Resolution Melting analysis as a rapid and efficient method of screening for small mutations in the STK11 gene in patients with Peutz-Jeghers syndrome.
|
23718779 |
2013 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.
|
23399955 |
2013 |
|
rs121913315
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
A novel de novo mutation in LKB1 gene in a Chinese Peutz Jeghers syndrome patient significantly diminished p53 activity.
|
21411391 |
2011 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.
|
21189378 |
2011 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Alu-mediated genomic deletion of the serine/threonine protein kinase 11 (STK11) gene in Peutz-Jeghers syndrome.
|
20435009 |
2010 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
|
19892943 |
2009 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome.
|
16582077 |
2006 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
An updated mutation spectrum in an Australian series of PJS patients provides further evidence for only one gene locus.
|
17026623 |
2006 |
|
rs121913315
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
|
15987703 |
2005 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome.
|
16287113 |
2005 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
|
14976552 |
2004 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
|
12865922 |
2003 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
|
14517248 |
2003 |
|
rs121913315
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients.
|
12372054 |
2002 |
|
rs121913315
|
|
A |
0.800 |
CausalMutation |
CLINVAR |
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.
|
10408777 |
1999 |
|
rs121913315
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.
|
10408777 |
1999 |
|
rs121913315
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
|
9428765 |
1998 |
|
rs121913315
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.
|
9425897 |
1998 |
|
rs121913315
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.
|
9760200 |
1998 |
|
rs121913315
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.
|
9837816 |
1998 |