|
rs4957796
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.
|
25533491 |
2015 |
|
rs4957796
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In conclusion, FER rs4957796 might act as a prognostic variable for survival in patients with severe ARDS due to pneumonia.
|
28851893 |
2017 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This case-control study evaluated the prevalence of D299G/T399I polymorphisms in Mexican patients with IAI and/or pneumonia and in healthy controls.
|
23871732 |
2013 |
|
rs5743708
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The presence of the TLR2 Arg753Gln polymorphism was significantly associated with pneumonia in AML patients (odds ratio (OR): 10.78; 95% confidence interval (CI): 2.0-58.23; P=0.006).
|
25427560 |
2015 |
|
rs5743708
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients carrying the TLR2 SNP rs5743708 (R753Q, GA/AA genotype, n = 12) also revealed a significantly higher susceptibility to pneumonia including IFD.
|
26963509 |
2016 |
|
rs1045411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the relationship between the high mobility group box protein B1 (HMGB1) single nucleotide polymorphisms (SNPs) rs1412125, rs2249825, and rs1045411 with pneumonia in terms of susceptibility, severity, and inflammatory response.
|
30562142 |
2019 |
|
rs1130866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous studies have indicated that a SP-B 1580C/T polymorphism (SNP rs1130866) was associated with lung diseases including pneumonia.
|
26620227 |
2016 |
|
rs1217371203
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To clarify the mechanism underlying these observations we have developed a model of lung inflammation using adoptively transferred CD4(+) T cells expressing a Valpha11(+)Vbeta3(+) transgenic TCR specific for I-E(k) and moth cytochrome c. Treatment with Y100F-Ig inhibited the induction of lung eosinophilia in adoptively transferred mice.
|
11290768 |
2001 |
|
rs12252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry.
|
23997235 |
2014 |
|
rs1412125
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs at the rs1412125 and rs2249825 loci of HMGB1 are associated with pneumonia in terms of susceptibility, severity, and inflammatory response.
|
30562142 |
2019 |
|
rs17615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One patient had 3 homozygous nonsynonymous variations of the complement receptor 2 (CR2) gene distributed in exons 10 (c.1916G>A, p.S639N) and 11 (c.1987T>C, p.S663P and c.2012G>A, p.R671H) with high frequency.This case series suggests that fungi are important respiratory pathogens in children with HIES and should be considered in cases of pneumonia in this population.
|
29620631 |
2018 |
|
rs17616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One patient had 3 homozygous nonsynonymous variations of the complement receptor 2 (CR2) gene distributed in exons 10 (c.1916G>A, p.S639N) and 11 (c.1987T>C, p.S663P and c.2012G>A, p.R671H) with high frequency.This case series suggests that fungi are important respiratory pathogens in children with HIES and should be considered in cases of pneumonia in this population.
|
29620631 |
2018 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis.
|
26025100 |
2015 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In intensive care unit patients, the TNF-α -308A allele and the IL-6 rs1800795 allele variants were susceptibility risk factors for septic shock induced by pneumonia.
|
26025100 |
2015 |
|
rs213950
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Caucasian and African American children with pneumonia were genotyped for the most common variants reported to affect cystic fibrosis transmembrane conductance regulator function, the p.508del mutation, the (TG)mTn variable repeat region, and the M470V polymorphism in the cystic fibrosis transmembrane conductance regulator gene.
|
22890249 |
2012 |
|
rs2249825
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs at the rs1412125 and rs2249825 loci of HMGB1 are associated with pneumonia in terms of susceptibility, severity, and inflammatory response.
|
30562142 |
2019 |
|
rs2294021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The relationships between FOXP3 rs3761547, rs3761548, rs3761549, rs2232365, rs2280883, and CCDC22 rs2294021 polymorphisms and clinical outcomes such as acute rejection, TAC-induced acute nephrotoxicity, and pneumonia were investigated by using Kaplan-Meier estimates and multivariate Cox regression analysis.
|
27747372 |
2017 |
|
rs4251961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher plasma IL-1ra was associated with an increased risk of infection (other than pneumonia), and the minor C allele of rs4251961 was independently associated with a decreased risk of infection (other than pneumonia).
|
24233813 |
2014 |
|
rs4308977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One patient had 3 homozygous nonsynonymous variations of the complement receptor 2 (CR2) gene distributed in exons 10 (c.1916G>A, p.S639N) and 11 (c.1987T>C, p.S663P and c.2012G>A, p.R671H) with high frequency.This case series suggests that fungi are important respiratory pathogens in children with HIES and should be considered in cases of pneumonia in this population.
|
29620631 |
2018 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
|
rs5743313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TLR3 rs5743313/CT polymorphism was found in all of the children with pneumonia and influenza infection, but in a significantly smaller number of those with A/H1N1/2009 influenza without pneumonia (<0.0001).
|
23151015 |
2012 |
|
rs587782477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To clarify the mechanism underlying these observations we have developed a model of lung inflammation using adoptively transferred CD4(+) T cells expressing a Valpha11(+)Vbeta3(+) transgenic TCR specific for I-E(k) and moth cytochrome c. Treatment with Y100F-Ig inhibited the induction of lung eosinophilia in adoptively transferred mice.
|
11290768 |
2001 |
|
rs601338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhea during ages 6-12 months and ages 12-24 months per additional risk (G) allele were 1.23 (95% confidence interval [CI], 1.08-1.4; P = .002) and 1.41 (95% CI, 1.24-1.61; P = 1.7 × 10-7), respectively; the risk ratio for ≥1 diagnosis of a lower respiratory illness (ie, pneumonia or bronchiolitis) during ages 12-24 months per additional G allele was 2.66 (95% CI, 1.64-4.3; P = .00007).
|
30376117 |
2019 |
|
rs7309123
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We could demonstrate that patients carrying the Dectin-1 SNP rs7309123 G/G (n = 47) or G/G and C/G (n = 133) genotype revealed a significant higher risk for developing both pneumonia in general (adjusted odds ratio (OR): 2.5; p = 0.014 and OR: 3.0, p = 0.004) and pulmonary IFD (OR: 2.6; p = 0.012 and OR: 2.4, p = 0.041, respectively).
|
26963509 |
2016 |