|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In sst2+/- mice, PI3K was activated and signaled via AKT (PKB; protein kinase B); when these mice were crossed with KRAS(G12D) mice, premalignant lesions, tumors, and lymph node metastases developed more rapidly than in KRAS(G12D) mice.
|
25683115 |
2015 |
|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although CA was observed in mammary tumors initiated by c-Myc or K-Ras(G12D), it was detected only in premalignant mammary lesions expressing K-Ras(G12D).
|
20581865 |
2010 |
|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Loss, or mutation, of Trp53 allows retention of the Kras(G12D)-expressing cells and drives rapid progression of these premalignant lesions to PDAC.
|
20018721 |
2010 |
|
rs10759932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR4 rs10759932, but not TLR2 rs3804099 and rs3804100, was associated with risk of premalignant and/or malignant and H. pylori susceptibility.
|
30301709 |
2019 |
|
rs1179251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the investigated gene variants onlyIL10T-819C, IL-8-251, IL-18RAP917997, IL-22 rs1179251, IL1-B-511, IL1-B-3954, IL4R-398 and IL1RN were identified as predictors for premalignant gastric lesions risk.
|
31435167 |
2019 |
|
rs3804099
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR4 rs10759932, but not TLR2 rs3804099 and rs3804100, was associated with risk of premalignant and/or malignant and H. pylori susceptibility.
|
30301709 |
2019 |
|
rs3804100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR4 rs10759932, but not TLR2 rs3804099 and rs3804100, was associated with risk of premalignant and/or malignant and H. pylori susceptibility.
|
30301709 |
2019 |
|
rs6061243
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two synonymous SNPs (rs6061243 and rs6587239) were associated with progression of premalignant gastric lesions in a dominant-effects model after correction for multiple comparisons (p = 2.63E-07 and p = 7.97E-07, respectively); effect sizes were β = -0.863 and β = -0.815, respectively, where β is an estimate of effect on histopathology scores, which ranged from 1 (normal) to 5 (dysplasia).
|
27225266 |
2016 |
|
rs6587239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two synonymous SNPs (rs6061243 and rs6587239) were associated with progression of premalignant gastric lesions in a dominant-effects model after correction for multiple comparisons (p = 2.63E-07 and p = 7.97E-07, respectively); effect sizes were β = -0.863 and β = -0.815, respectively, where β is an estimate of effect on histopathology scores, which ranged from 1 (normal) to 5 (dysplasia).
|
27225266 |
2016 |
|
rs104894230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In sst2+/- mice, PI3K was activated and signaled via AKT (PKB; protein kinase B); when these mice were crossed with KRAS(G12D) mice, premalignant lesions, tumors, and lymph node metastases developed more rapidly than in KRAS(G12D) mice.
|
25683115 |
2015 |
|
rs727503094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In sst2+/- mice, PI3K was activated and signaled via AKT (PKB; protein kinase B); when these mice were crossed with KRAS(G12D) mice, premalignant lesions, tumors, and lymph node metastases developed more rapidly than in KRAS(G12D) mice.
|
25683115 |
2015 |
|
rs752021744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In sst2+/- mice, PI3K was activated and signaled via AKT (PKB; protein kinase B); when these mice were crossed with KRAS(G12D) mice, premalignant lesions, tumors, and lymph node metastases developed more rapidly than in KRAS(G12D) mice.
|
25683115 |
2015 |
|
rs10893506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphism analysis showed that at SNP rs10893506, genotypes CC and CT of the ST3GAL4 B3 promoter were associated with the presence of premalignant lesions (OR=2.89; 95%CI 1.72-4.85) and cervical cancer (OR=2.23; 95%CI 1.27-3.91).
|
24606438 |
2014 |
|
rs61748181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings warrant further analysis of A279T expression in esophageal cancers and premalignant esophageal lesions.
|
24983628 |
2014 |
|
rs9527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a follow-up analysis of 1,085 individuals with arsenic-induced premalignant skin lesions (the classical sign of arsenic toxicity) and 1,794 controls, we show that one of these five variants (rs9527) is also associated with skin lesion risk (P = 0.0005).
|
22383894 |
2012 |
|
rs762846821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Loss, or mutation, of Trp53 allows retention of the Kras(G12D)-expressing cells and drives rapid progression of these premalignant lesions to PDAC.
|
20018721 |
2010 |
|
rs11191439
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that Met287Thr influences the susceptibility to premalignant As skin lesions and might be at increased risk for other adverse health effects of iAs exposure.
|
19538983 |
2009 |
|
rs79658334
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CCH associated with V804M RET mutation is a precancerous condition and surgery is recommended.
|
18299477 |
2008 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutations in the BRAF gene causing a V599E amino acid substitution that enhance the kinase activity have been described in >60% of cutaneous melanomas and premalignant melanocytic lesions.
|
14522889 |
2003 |
|
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutations in the BRAF gene causing a V599E amino acid substitution that enhance the kinase activity have been described in >60% of cutaneous melanomas and premalignant melanocytic lesions.
|
14522889 |
2003 |