Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs137852578
rs137852578
AR
0.020 GeneticVariation BEFREE Human LNCaP cells, extensively used as a model for androgen-dependent prostate tumor, express the androgen receptor (AR) mutant T877A promiscuously transactivated by estrogens and other ligands, which may further facilitate cancer progression. 12391264

2002

dbSNP: rs137852581
rs137852581
AR
0.010 GeneticVariation BEFREE CWR22Rv1 (22Rv1) is an androgen-responsive human prostate carcinoma cell line derived from a primary prostate tumor that expresses mutant (H874Y) androgen receptors (AR) and secretes low levels of prostate specific antigen (PSA). 15249132

2004

dbSNP: rs486907
rs486907
0.020 GeneticVariation BEFREE Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. 16609730

2006

dbSNP: rs28909982
rs28909982
0.010 GeneticVariation BEFREE In this study, we have identified two novel somatic CHEK2 mutations, c.349A > G (p.R117G) and c.967A > C (p.E321K), in prostate tumor specimens and investigated the functions of these mutants in vivo. 16835864

2006

dbSNP: rs587782480
rs587782480
0.010 GeneticVariation BEFREE In this study, we have identified two novel somatic CHEK2 mutations, c.349A > G (p.R117G) and c.967A > C (p.E321K), in prostate tumor specimens and investigated the functions of these mutants in vivo. 16835864

2006

dbSNP: rs786202601
rs786202601
0.010 GeneticVariation BEFREE In this study, we have identified two novel somatic CHEK2 mutations, c.349A > G (p.R117G) and c.967A > C (p.E321K), in prostate tumor specimens and investigated the functions of these mutants in vivo. 16835864

2006

dbSNP: rs1571801
rs1571801
0.010 GeneticVariation BEFREE Analysis of the distribution of these SNPs among 1032 prostate cancer patients and 571 control subjects of European descent indicated that one, rs1571801, located in the DAB2IP gene, which encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor, was associated with aggressive prostate cancer (one-sided P value = .004). 18073375

2007

dbSNP: rs113488022
rs113488022
0.010 GeneticVariation BEFREE In the course of modeling malignant melanoma in a tyrosinase promoter transgenic system, we developed a genetically-engineered mouse (GEM) model of invasive prostate cancers, whereby an activating mutation of BRAF(V6</span>00E)--a mutation found in approximately 10% of human prostate tumors--was targeted to the epithelial compartment of the prostate gland on the background of Ink4a/Arf deficiency. 19079609

2008

dbSNP: rs121913377
rs121913377
0.010 GeneticVariation BEFREE In the course of modeling malignant melanoma in a tyrosinase promoter transgenic system, we developed a genetically-engineered mouse (GEM) model of invasive prostate cancers, whereby an activating mutation of BRAF(V6</span>00E)--a mutation found in approximately 10% of human prostate tumors--was targeted to the epithelial compartment of the prostate gland on the background of Ink4a/Arf deficiency. 19079609

2008

dbSNP: rs976306779
rs976306779
AR
0.010 GeneticVariation BEFREE In our study, we evaluated the functional significance of S100P expression on prostate tumor growth in vitro and in vivo. 18452169

2008

dbSNP: rs486907
rs486907
0.020 GeneticVariation BEFREE A novel gammaretrovirus named xenotropic murine leukemia virus-related virus (XMRV) has been recently identified and found to have a prevalence of 40% in prostate tumor samples from American patients carrying a homozygous R462Q mutation in the RNaseL gene. 19835577

2009

dbSNP: rs1512268
rs1512268
0.010 GeneticVariation BEFREE Genome-wide association studies (GWAS) identified multiple susceptible loci for prostate cancer (PC), and recent GWAS implicated that a common variant rs1512268 on chromosome 8p21 is associated with PC susceptibility, which is located at 14 kb downstream of a prostate tumor suppressor gene NKX3.1. 20716579

2010

dbSNP: rs16861209
rs16861209
0.010 GeneticVariation BEFREE Two of the risk SNPs (rs266729 and rs182052) plus four other SNPs (rs16861209, rs17366568, rs3774261, and rs7639352) were also associated with plasma adiponectin levels, and three of these (rs1686109, rs17366568, and rs3774261) were also significantly associated with IR expression in prostate tumor tissue. 21960694

2011

dbSNP: rs17366568
rs17366568
0.010 GeneticVariation BEFREE Two of the risk SNPs (rs266729 and rs182052) plus four other SNPs (rs16861209, rs17366568, rs3774261, and rs7639352) were also associated with plasma adiponectin levels, and three of these (rs1686109, rs17366568, and rs3774261) were also significantly associated with IR expression in prostate tumor tissue. 21960694

2011

dbSNP: rs182052
rs182052
0.010 GeneticVariation BEFREE Two of the risk SNPs (rs266729 and rs182052) plus four other SNPs (rs16861209, rs17366568, rs3774261, and rs7639352) were also associated with plasma adiponectin levels, and three of these (rs1686109, rs17366568, and rs3774261) were also significantly associated with IR expression in prostate tumor tissue. 21960694

2011

dbSNP: rs266729
rs266729
0.010 GeneticVariation BEFREE Two of the risk SNPs (rs266729 and rs182052) plus four other SNPs (rs16861209, rs17366568, rs3774261, and rs7639352) were also associated with plasma adiponectin levels, and three of these (rs1686109, rs17366568, and rs3774261) were also significantly associated with IR expression in prostate tumor tissue. 21960694

2011

dbSNP: rs3774261
rs3774261
0.010 GeneticVariation BEFREE Two of the risk SNPs (rs266729 and rs182052) plus four other SNPs (rs16861209, rs17366568, rs3774261, and rs7639352) were also associated with plasma adiponectin levels, and three of these (rs1686109, rs17366568, and rs3774261) were also significantly associated with IR expression in prostate tumor tissue. 21960694

2011

dbSNP: rs7639352
rs7639352
0.010 GeneticVariation BEFREE Two of the risk SNPs (rs266729 and rs182052) plus four other SNPs (rs16861209, rs17366568, rs3774261, and rs7639352) were also associated with plasma adiponectin levels, and three of these (rs1686109, rs17366568, and rs3774261) were also significantly associated with IR expression in prostate tumor tissue. 21960694

2011

dbSNP: rs137852578
rs137852578
AR
0.020 GeneticVariation BEFREE The gene expression profile of AR-E231G prostate tissue from 12-week-old mice was compared to an equivalent profile from mice expressing the AR-T857A receptor variant (analogous to the AR-T877A variant in LNCaP cells), which do not develop prostate tumors. 22275114

2012

dbSNP: rs138213197
rs138213197
0.030 GeneticVariation BEFREE PSA testing, six-core biopsy, genetic counselling and mutation analysis for French Canadian founder mutations in the BRCA1 and BRCA2 genes, histopathological review of tumour tissue from family members, examination of loss of heterozygosity at the BRCA2 gene locus, immunohistochemistry to determine the expression of the ERG nuclear oncoprotein in prostate tumours, genotyping with eight selected risk-associated single nucleotide polymorphisms, Doppler ultrasonography of the leg, CT of the abdomen and pelvis with intravenous and oral contrast, chest CT with intravenous contrast for the assessment of metastatic prostate cancer, genetic testing for the G84E variant in the HOXB13 gene. 23318356

2013

dbSNP: rs1057519912
rs1057519912
0.010 GeneticVariation BEFREE So far, the recently reported MED12 p.L1224F mutation could not be validated in our unselected cohort of prostate tumours. 23661306

2013

dbSNP: rs121913430
rs121913430
A 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs339331
rs339331
0.010 GeneticVariation BEFREE Finally, we observe a significant association between the risk-associated T allele at rs339331 and increased RFX6 mRNA levels in human prostate tumors. 24390282

2014

dbSNP: rs375118292
rs375118292
0.010 GeneticVariation BEFREE Analysis of the prostate tumor from this individual verified the presence of heterozygous N296I as well as an ERG fusion. 24796539

2014

dbSNP: rs727502792
rs727502792
0.010 GeneticVariation BEFREE Analysis of the prostate tumor from this individual verified the presence of heterozygous N296I as well as an ERG fusion. 24796539

2014