|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.
|
29389950 |
2018 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aims to assess whether the association between the non-susceptibility allelic variants of IL12B single-nucleotide polymorphism (SNPs) rs3212227 and rs6887695, IL23R SNPs rs11209026 and rs7530511, IL6 SNP rs1800795 and HLA-Cw6 could be correlated with decreased risk for psoriasis.
|
24140476 |
2014 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study showed significant associations between psoriasis and both IL12B gene SNPs, rs3212227 (odds ratio (OR) = 1.35, P = 4.94E-04) and rs6887695 (OR = 1.32, P = 2.00E-03), but no significant association between psoriasis and the IL23R SNP, rs11209026.
|
23955419 |
2013 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genetic polymorphism of the IL-12B gene (rs6887695) may be associated with the psoriasis susceptibility in the Chinese Han population, especially for the plaque cases, but not associated with the age at onset, family history, or sex.
|
23564024 |
2013 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis showed that the IL-23 R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.
|
23844553 |
2013 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Then, for rs6887695, the pooled ORs were 0.704 (95 % CI 0.670-0.739) for psoriasis and 0.677 (95 % CI 0.599-0.767) for PsA.
|
23297015 |
2013 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One of the IL12B markers, rs3212227, showed significant association with psoriasis (OR = 1.64, P = 0.0058) while the other, rs6887695, did not (OR = 1.29, P = 0.12).
|
19705136 |
2010 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the relationships of these predisposing polymorphisms with psoriasis in the Chinese Han population, we genotyped three representative variants (rs6887695</span>, rs11465817, and rs1343152) in 217 unrelated patients and 288 control subjects using direct sequencing, We further replicated the positive polymorphism, rs6887695, in a larger combined sample that included 578 patients and 1422 controls.
|
20875477 |
2010 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both IL12B markers showed highly significant association with psoriasis in the case-control (rs3212227, odds ratio (OR)=1.62, P=1.7 x 10(-15); rs6887695, OR=1.49, P=2.7 x 10(-15)) and in the family-based analysis (rs3212227, P=2.2 x 10(-3); rs6887695, P=1.7 x 10(-3)).
|
18219280 |
2008 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We replicated the previously reported association with interleukin 23 receptor and interleukin 12B (IL12B) polymorphisms in PS and PSA cohorts (IL23R: rs11209026, U.S. PS, P = 1.4x10(-4); U.K. PSA: P = 8.0x10(-4); IL12B:rs6887695, U.S. PS, P = 5x10(-5) and U.K. PSA, P = 1.3x10(-3)) and detected an independent association in the IL23R region with a SNP 4 kb upstream from IL12RB2 (P = 0.001).
|
18369459 |
2008 |
|
rs6887695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotypes were estimated, and genotype-conditioned analyses identified a second risk allele (rs6887695) located approximately 60 kb upstream of the IL12B coding region that exhibited association with psoriasis after adjustment for rs3212227.
|
17236132 |
2007 |