|
rs1006737
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
rs1006737
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ.
|
27790829 |
2017 |
|
rs1006737
|
|
|
0.730 |
GeneticVariation |
GWASDB |
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
|
24280982 |
2014 |
|
rs1006737
|
|
|
0.730 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |
|
rs1009080
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
|
20889312 |
2010 |
|
rs10275045
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
|
24280982 |
2014 |
|
rs1039002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸).
|
22205951 |
2011 |
|
rs10462023
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2290036-C variant of ARNTL was over-represented in psychosis patients, and the variants rs934945-G and rs10462023-G of PER2 were associated with a more severe psychotic disorder.
|
25799324 |
2015 |
|
rs104894685
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The authors identified a missense mutation in the FTL gene (474G>A; A96T) in a 19-year-old man with parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit, and episodic psychosis.
|
16116125 |
2005 |
|
rs1049353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we have tested whether three CNR1 variants (rs1049353, rs1535255 and rs2023239) are associated with changes in brain volumes, body mass index (BMI) or psychopathological scores in a 3-year longitudinal study of 65 first-episode psychosis patients.
|
26071625 |
2015 |
|
rs10494561
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our analyses found that rs10494561, located in the intron region within NMNAT2, was associated with the severity of the prodromal symptoms of psychosis implicitly, mediated through the volume of the left hemisphere of the superior frontal region ( P=2.38×10-8).
|
28544218 |
2017 |
|
rs10496702
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
|
20889312 |
2010 |
|
rs10496702
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
|
20889312 |
2010 |
|
rs10503929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a 3-year prospective study cohort of 185 individuals (age: 13-35 years) at high risk and ultra-high risk (UHR) for psychosis, we assessed <i>DAO</i> (rs3918347, rs4623951), <i>DAOA</i> (rs778293, rs3916971, rs746187), and <i>NRG1</i> (rs10503929) SNPs and their mRNA expression.
|
29326614 |
2017 |
|
rs1076560
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, variation of the DRD2, rs1076560, genotype may modulate the psychosis-inducing effect of cannabis use.
|
25829376 |
2015 |
|
rs1076560
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings did not provide evidence of a possible role of COMT Val<sup>158</sup>Met, AKT1 rs2494732 or DRD2 rs1076560 genotypes in modifying the association between childhood adversity and onset of psychosis.
|
29653893 |
2019 |
|
rs10868235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Depressive disorders accounted for this results and independent variables associated with depressive disorders in TLE were female sex (OR=2.59; 95%CI=1.15-5.82; p=0.021), presence of concomitant anxiety disorders (OR=3.72; 95%CI=1.71-8.06; p=0.001) or psychotic disorders (OR=3.86; 95%CI=1.12-13.25; p=0.032), A/A genotype in the rs1867283 NTRK2 gene (OR=3.06; 95%CI=1.25-7.50; p=0.015) and C/C genotype in the rs10868235 NTRK2 gene (OR=3.54; 1.55-8.08; p=0.003).
|
28550723 |
2017 |
|
rs10949808
|
|
T |
0.800 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
|
20889312 |
2010 |
|
rs10949808
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
|
20889312 |
2010 |
|
rs10994359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A history of suicide attempt was assessed in a sample of 1009 patients with BD, SCZ and related psychosis spectrum disorders, and associations with the joint genetic risk variants for BD and SCZ (rs2239547 (ITIH3/4-region), rs10994359 (ANK3) and rs4765905 (CACNA1C)) were investigated.
|
24461634 |
2014 |
|
rs11164835
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
|
20889312 |
2010 |
|
rs1126442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present findings indicate that the rs1126442 of GRIN1 contributes to the genetic vulnerability to psychosis in METH-dependent subjects in the Thai population.
|
23880023 |
2013 |
|
rs1130214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
None of the effects reported in earlier studies were statistically significant, including the association between rs3803300 and BD without any psychotic symptoms, rs3803300 and mood-congruent psychosis, rs3803300 and the combined groups, as well as the association between the haplotypes formed by rs3730358 and rs1130214 and risk for BD.
|
31810747 |
2020 |
|
rs1137101
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The LEPR Q223R polymorphism may be a risk factor for obesity in women with a psychotic disorder treated with atypical antipsychotic drugs.
|
21510767 |
2011 |
|
rs1137101
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To determine whether genetic polymorphisms related to pharmacodynamics with metabolic adverse effects, namely leptin promoter (<i>LEP</i>) rs7799039, leptin receptor rs1137101, dopamine D2 rs4436578, serotonin 5-HT2A rs6313, and serotonin 5-HT2C rs518147 and rs12836771, are associated with hyperglycemia induced by risperidone or clozapine in adult Thai patients with psychosis.
|
31496784 |
2019 |